Integrin beta 1
Integrins are transmembrane receptors that mediate the attachment between a cell and its surroundings, such as other cells or the extracellular matrix (ECM). Integrins are obligate heterodimers containing two distinct chains, called the α (alpha) and β (beta) subunits. The molecular mass of the integrin subunits can vary from 90 kDa to 160 kDa. Beta subunits have four cysteine-rich repeated sequences. Both α and β subunits bind several divalent cations. Integrins have two main functions: Attachment of the cell to the ECM and signal transduction from the ECM to the cell. However, they are also involved in a wide range of other biological activities, including immune patrolling, cell migration, and binding to cells by certain viruses, such as adenovirus, echovirus, hantavirus, and foot and mouth disease viruses. Research studies have implicated β1 integrin in various activities including embryonic development, blood vessel, skin, bone, and muscle formation, as well as tumor metastasis and angiogenesis.
Human, Mouse, Rat, zebrafish
Recombinant Rabbit Monoclonal Antibody
Hela, NIH/3T3, human liver cancer tissue, human colon cancer tissue, mouse stomach tissue.
beta1 integrin antibody
Fibronectin receptor subunit beta antibody
Glycoprotein IIa antibody
GP IIa antibody
Integrin beta-1 antibody
integrin VLA-4 beta subunit antibody
Integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) antibody
Very late activation protein, beta polypeptide antibody
VLA BETA antibody
VLA-4 subunit beta antibody
Store at +4℃ after thawing. Aliquot store at -20℃ or -80℃. Avoid repeated freeze / thaw cycles.
1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.
ProA affinity purified
Cell Membrane, Cell projection, Cleavage furrow
Fig1: Western blot analysis of Integrin beta 1 on different cell lysates using anti-Integrin beta 1 antibody at 1/1,000 dilution. Positive control:
Lane 1: Hela
Lane 2: NIH/3T3
Fig2: Immunohistochemical analysis of paraffin-embedded human liver cancer tissue using anti-Integrin beta 1 antibody. Counter stained with hematoxylin.
Fig3: Immunohistochemical analysis of paraffin-embedded human colon cancer tissue using anti-Integrin beta 1 antibody. Counter stained with hematoxylin.
Fig4: Immunohistochemical analysis of paraffin-embedded mouse stomach tissue using anti-Integrin beta 1 antibody. Counter stained with hematoxylin.
1. "Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry." Chen R. Jiang X. Sun D. Han G. Wang F., Ye M. Wang L. Zou H. J. Proteome Res. 8:651-661(2009).
2. "Osteoblast mineralization requires beta1 integrin/ICAP-1-dependent fibronectin deposition." Brunner M. Millon-Fremillon A. Chevalier G. Nakchbandi I.A. Mosher D. Block M.R. Albiges-Rizo C. Bouvard D. J. Cell Biol. 194:307-322(2011).
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