The membrane-bound isoform 1 is a receptor involved in the development of the cardiovascular system, in angiogenesis, in the formation of certain neuronal circuits and in organogenesis outside the nervous system. It mediates the chemorepulsant activity of semaphorins. It binds to semaphorin 3A, The PLGF-2 isoform of PGF, The VEGF165 isoform of VEGFA and VEGFB. Coexpression with KDR results in increased VEGF165 binding to KDR as well as increased chemotaxis. Regulate VEGF-induced angiogenesis. Binding to VEGFA initiates a signaling pathway needed for motor neuron axon guidance and cell body migration, including for the caudal migration of facial motor neurons from rhombomere 4 to rhombomere 6 during embryonic development.
Mouse Monoclonal Antibody
Hela, mouse brain tissue
Brain specific transmembrane protein containing 2 CUB and 1 LDL receptor class A domains protein 1 antibody
Brain-specific transmembrane protein containing 2 CUB and 1 LDL-receptor class A domains protein 1 antibody
Neuropilin and tolloid like 1 antibody
Neuropilin and tolloid-like protein 1 antibody
Store at +4℃ after thawing. Aliquot store at -20℃. Avoid repeated freeze / thaw cycles.
1*PBS (pH7.4), 0.2% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
ProA affinity purified
Fig1: Western blot analysis on recombinant protein using anti-Neuropilin 1 Mouse mAb (Cat. # M0910-5).
Fig2：Immunofluorescent staining of Hela cells using anti-Neuropilin 1 Mouse mAb (Cat. # M0910-5).
Fig3：Immunohistochemical analysis of paraffin- embedded mouse brain tissue using anti-Neuropilin 1 Mouse mAb (Cat. # M0910-5).
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To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
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