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β-Catenin

Product code: 0407-16


  • Overview

  • Product name β-Catenin
  • Molecular Wt 86 kDa
  • Description β-Catenin is a multifunctional adaptor protein involved in cadherin-mediated cell–cell adhesion and in responding to the activation of several signal transduction pathways. CK1 phosphorylates β-catenin on Ser45. This phosphorylation event primes β-catenin for subsequent phosphorylation by GSK-3. GSK-3β destabilizes β-catenin by phosphorylating it at Ser33, Ser37 and Thr41.). Mutations in β-Catenin have been implicated in its accumulation and various forms of carcinomas.
  • Species reactivity Human,mouse,rat, zebrafish
  • Tested applications WB,ICC,IHC
  • Antibody type Rabbit Polyclonal Antibody
  • Immunogen peptide
  • Positive control A431, SW480
  • Conjugate Non-conjugated
  • Alternative names Beta catenin antibody
    Beta-catenin antibody
    Cadherin associated protein antibody
    Catenin (cadherin associated protein), beta 1, 88kDa antibody
    Catenin beta 1 antibody
    Catenin beta-1 antibody
    CATNB antibody
    CHBCAT antibody
    CTNB1_HUMAN antibody
    CTNNB antibody
    CTNNB1 antibody
    DKFZp686D02253 antibody
    FLJ25606 antibody
    FLJ37923 antibody
    OTTHUMP00000162082 antibody
    OTTHUMP00000165222 antibody
    OTTHUMP00000165223 antibody
    OTTHUMP00000209288 antibody
    OTTHUMP00000209289 antibody
  • Properties

  • Form Liquid
  • Concentration 1 mg/mL.
  • Storage instructions Store at +4℃ after thawing. Aliquot store at -20℃ or -80℃. Avoid repeated freeze / thaw cycles.
  • Buffer 1*PBS (pH7.4), 0.2% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
  • Isotype IgG
  • Purity Immunogen affinity purified
  • Subcellular location Cell membrane, perinuclear region
  • Database links Q02248
  • Applications

    WB 1:5,000
    ICC: 1:200

  • Publishing research using β-Catenin? Please let us know so that we can cite the reference in this datasheet.

  • Xiang, B., Chen, L., Wang, X., Zhao, Y., Wang, Y., & Xiang, C. (2017). Transplantation of Menstrual Blood-Derived Mesenchymal Stem Cells Promotes the Repair of LPS-Induced Acute Lung Injury. Int J Mol Sci, 18(4). PMID: 28346367
  • Zhu, X., Wang, W., Zhang, X., Bai, J., Chen, G., Li, L., & Li, M. (2015). All-Trans Retinoic Acid-Induced Deficiency of the Wnt/beta-Catenin Pathway Enhances Hepatic Carcinoma Stem Cell Differentiation. PLoS One, 10(11), e0143255. PMID: 26571119

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Specific Protocols

To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.

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