β-Catenin is a multifunctional adaptor protein involved in cadherin-mediated cell–cell adhesion and in responding to the activation of several signal transduction pathways. CK1 phosphorylates β-catenin on Ser45. This phosphorylation event primes β-catenin for subsequent phosphorylation by GSK-3. GSK-3β destabilizes β-catenin by phosphorylating it at Ser33, Ser37 and Thr41.). Mutations in β-Catenin have been implicated in its accumulation and various forms of carcinomas.
Rabbit Polyclonal Antibody
Beta catenin antibody
Cadherin associated protein antibody
Catenin (cadherin associated protein), beta 1, 88kDa antibody
Catenin beta 1 antibody
Catenin beta-1 antibody
Store at +4℃ after thawing. Aliquot store at -20℃ or -80℃. Avoid repeated freeze / thaw cycles.
1*PBS (pH7.4), 0.2% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Immunogen affinity purified
Cell membrane, perinuclear region
Fig1: Western blot analysis on cell lysates using anti-β-Catenin polyclonal antibody
Fig2: Western blot analysis of β-Catenin on hybrid fish (crucian-carp) heart tissue lysate using anti-β-Catenin antibody at 1/500 dilution.
Fig3: ICC staining β-Catenin (green) in Hela cells. Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS.
Publishing research using β-Catenin? Please let us know so that we can cite the reference in this datasheet.
Xiang, B., Chen, L., Wang, X., Zhao, Y., Wang, Y., & Xiang, C. (2017). Transplantation of Menstrual Blood-Derived Mesenchymal Stem Cells Promotes the Repair of LPS-Induced Acute Lung Injury. Int J Mol Sci, 18(4).
Zhu, X., Wang, W., Zhang, X., Bai, J., Chen, G., Li, L., & Li, M. (2015). All-Trans Retinoic Acid-Induced Deficiency of the Wnt/beta-Catenin Pathway Enhances Hepatic Carcinoma Stem Cell Differentiation. PLoS One, 10(11), e0143255.
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