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LRP1 [SA0290]

Product code: ET1601-1

  • Overview

  • Product name LRP1
  • Molecular Wt 85 kDa
  • Description Members of the LDL receptor gene family, including LDLR (low density lipoprotein receptor), LRP1 (low density lipoprotein related protein), Megalin (also designated GP330), VLDLR (very low density lipoprotein receptor) and ApoER2 are characterized by a cluster of cysteine-rich class A repeats, epidermal growth factor (EGF)-like repeats, YWTD repeats and an O-linked sugar domain. LRP1, also designated LRP and ?-2-Macroglobulin receptor, is an endocytic receptor that mediates the uptake of at least 15 ligands, including ?-2-Macroglobulin and apoE. LRP1 is cleaved into a membrane subunit and an extracellular subunit, which remain non-covalently associated. Proper folding and trafficking of LRP1 is facilitated by the receptor-associated protein (RAP), a molecular chaperone. The uptake of all known ligands through LRP1 can be blocked by RAP, which induces a conformational change in the receptor that renders it unable to bind ligands. LRP1, which is expressed in brain, liver and lung, is also implicated in Alzheimer’s disease (AD), as the human LRP gene localizes to a potential AD locus on chromosome 12.
  • Species reactivity Human, Mouse, (Predicted: Rat)
  • Tested applications WB,ICC/IF,IHC-P,IP,FC
  • Antibody type Recombinant Rabbit Monoclonal Antibody
  • Immunogen Synthetic peptide within human LRP1 aa 4480-4520(85kDa).
  • Positive control Mouse liver tissue lysate, mouse brain tissue lysate, mouse lung tissue lysate, human liver tissue lysate, HepG2 cell lysate, human lung tissue lysate, Hela, MCF-7, HUVEC, human lung tissue, mouse brain tissue, mouse liver tissue, human liver tissue.
  • Conjugate Non-conjugated
  • Clone number SA0290
  • Alternative names A2MR antibody
    Alpha 2 macroglobulin receptor antibody
    alpha 2MR antibody
    Alpha-2-macroglobulin receptor antibody
    APOER antibody
    Apolipoprotein E receptor antibody
    APR antibody
    CD 91 antibody
    CD91 antibody
    CD91 antigen antibody
    IGFBP3R antibody
    LDL receptor related protein 1 antibody
    Low density lipoprotein receptor related protein 1 antibody
    Low density lipoprotein related protein 1 antibody
    Low-density lipoprotein receptor-related protein 1 intracellular domain antibody
    LRP 1 antibody
    LRP 515 antibody
    LRP 85 antibody
    LRP antibody
    LRP ICD antibody
    LRP-1 antibody
    LRP-515 antibody
    LRP-85 antibody
    Lrp1 antibody
    LRP1 protein antibody
    LRP1_HUMAN antibody
    LRP1A antibody
    LRP515 antibody
    LRP85 antibody
    LRPICD antibody
    MGC88725 antibody
    Prolow density lipoprotein receptor related protein 1 antibody
    TbetaR V/LRP 1/IGFBP 3 receptor antibody
    TbetaRV/LRP1/IGFBP3 receptor antibody
    TGFBR 5 antibody
    TGFBR5 antibody
    Type V tgf beta receptor antibody
    Low-density lipoprotein receptor-related protein 1 85 kDa subunit
  • Properties

  • Form Liquid
  • Concentration 1 mg/mL.
  • Storage instructions Store at +4℃ after thawing. Aliquot store at -20℃ or -80℃. Avoid repeated freeze / thaw cycles.
  • Buffer 1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
  • Isotype IgG
  • Purity Protein A affinity purified.
  • Subcellular location Cytoplasm, Nucleus, Membrane.
  • Database links SwissProt: Q07954 Human
    SwissProt: Q91ZX7 Mouse
    SwissProt: G3V928 Rat
  • Applications

    WB: 1:500-1:5,000
    ICC/IF: 1:50-1:200
    IHC-P: 1:50-1:200
    FC: 1:50-1:100
    IP: Use at an assay dependent concentration.

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Specific Protocols

To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.

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