Rabbit polyclonal primary
ZO1 Antibody (ER41204)
MCF-7, human tonsil tissue, mouse kidney tissue.
Store at +4C after thawing. Aliquot store at -20C or -80C. Avoid repeated freeze / thaw cycles.
1*PBS (pH7.4), 0.2% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Peptide affinity purified
Tight junction protein 1 antibody; Tight junction protein ZO-1 antibody; Tight junction protein ZO1 antibody; TJP1 antibody; zo-1 antibody; Zo1 antibody; ZO1_HUMAN antibody; Zona occludens 1 antibody; Zona occludens 1 protein antibody; Zona occludens protein 1 antibody; Zonula occludens 1 protein antibody; Zonula occludens protein 1 antibody
Belongs to the MAGUK family.
The alpha-containing isoform is found in most epithelial cell junctions. The short isoform is found both in endothelial cells and the highly specialized epithelial junctions of renal glomeruli and Sertoli cells of the seminiferous tubules.
Phosphorylated at tyrosine redidues in response to epidermal growth factor (EGF). This response is dependent on an intact actin microfilament system. Dephosphorylated by PTPRJ.
Cell membrane, cell junction
Tight junction protein ZO-1 is a protein that in humans is encoded by the TJP1 gene. This gene encodes a protein located on a cytoplasmic membrane surface of intercellular tight junctions. The N-terminal may be involved in transducing a signal required for tight junction assembly, while the C-terminal may have specific properties of tight junctions. The alpha domain might be involved in stabilizing junctions. ZO1 plays a role in the regulation of cell migration by targeting CDC42BPB to the leading edge of migrating cells.