Positive control:
Lane 1: human kidney tissue lysate
Lane 2: HepG2 cell lysate
Applications
-
WB
-
ICC
-
IHC-P
-
FC
REACTIVITY
-
Human
-
Mouse
-
Rat
SPECIFICATIONS
Product Type
Rabbit polyclonal primary
Product Name
ZAC Antibody (ER1901-48)
Immunogen
Synthetic peptide within human zac aa 100-200.
Host
Rabbit
Positive Control
Human kidney tissue lysate, HepG2 cell lysate, N2A, SiHa, rat brain tissue, human liver tissue, human kidney tissue, mouse cerebellum tissue, SH-SY5Y.
Conjugation
Unconjugated
Clonality
Polyclonal
PROPERTIES
Form
Liquid
Storage Condition
Store at +4C after thawing. Aliquot store at -20C. Avoid repeated freeze / thaw cycles.
Storage Buffer
1*PBS (pH7.4), 0.2% BSA, 50% Glycerol. Preservative: 0.05% Sodium Azide.
Concentration
1 ug/ul
PURIFICATION
Peptide affinity purified.
MOLECULAR WEIGHT
46 kDa
Isotype
IgG
APPLICATION DILUTION
-
WB:1:500-1:2,000
-
ICC:1:50-1:100
-
IHC-P:1:50-1:200
-
FC:1:50-1:100
TARGET
UNIPROT #
PROTEIN NAME
ZAC
SYNONYMS
Zinc-activated ligand-gated ion channel; Ligand-gated ion channel zinc-activated 1; Ligand-gated ion-channel receptor L2; L2; LGICZ; LGICZ1; ZAC
SEQUENCE SIMILARITIES
Belongs to the ligand-gated ion channel (TC 1.A.9) family.
TISSUE SPECIFICITY
Detected in pancreas, brain, liver, placenta, trachea, kidney, spinal cord, stomach and fetal brain. In the adult brain region expression is detected in the hippocampus, striatum, amygdala and thalamus.
POST-TRANSLATIONAL MODIFICATION
Glycosylated.
SUBCELLULAR LOCATION
Cell membrane.
FUNCTION
Zinc-activated ion channel (ZAC), is a human protein encoded by the ZACN gene. ZAC forms a cation-permeable ligand-gated ion channel of the "Cys-loop" superfamily. The ZAC gene is present in humans and dogs, but no ortholog is thought to exist in the rat or mouse genomes. ZAC mRNA is expressed in prostate, thyroid, trachea, lung, brain (adult and fetal), spinal cord, skeletal muscle, heart, placenta, pancreas, liver, kidney and stomach. The endogenous ligand for ZAC is thought to be Zn2+, although ZAC has also been found to activate spontaneously. The function of spontaneous ZAC activation is unknown.