Applications
-
ICC
-
IHC-P
REACTIVITY
-
Human
SPECIFICATIONS
Product Type
Rabbit polyclonal primary
Product Name
USP36 Antibody (ER1706-23)
Immunogen
Peptide
Host
Rabbit
Positive Control
A549, Hela, LOVO, human liver cancer tissue, human spleen tissue.
Conjugation
Unconjugated
Clonality
Polyclonal
PROPERTIES
Form
Liquid
Storage Condition
Store at +4C after thawing. Aliquot store at -20C or -80C. Avoid repeated freeze / thaw cycles.
Storage Buffer
1*PBS (pH7.4), 0.2% BSA, 50% Glycerol. Preservative: 0.05% Sodium Azide.
Concentration
1 ug/ul
PURIFICATION
Peptide affinity purified
MOLECULAR WEIGHT
123 kDa
Isotype
IgG
APPLICATION DILUTION
-
ICC
-
1:50-1:200
-
IHC-P
-
1:50-1:200
TARGET
UNIPROT #
PROTEIN NAME
USP36
SYNONYMS
Deubiquitinating enzyme 1 antibody; Deubiquitinating enzyme 36 antibody; DUB1 antibody; FLJ12851 antibody; KIAA1453 antibody; Ubiquitin carboxyl-terminal hydrolase 36 antibody; Ubiquitin specific peptidase 36 antibody; Ubiquitin specific processing protease 36 antibody; Ubiquitin thioesterase 36 antibody; Ubiquitin thiolesterase 36 antibody; Ubiquitin-specific-processing protease 36 antibody; UBP36_HUMAN antibody; Usp36 antibody
SEQUENCE SIMILARITIES
Belongs to the peptidase C19 family.
TISSUE SPECIFICITY
Broadly expressed.
POST-TRANSLATIONAL MODIFICATION
Polyubiquitinated by NEDD4L, no effect on USP36 protein levels. Both proteins interact with and regulate each other's ubiquitination levels.
SUBCELLULAR LOCATION
Nucleus.
FUNCTION
Ubiquitin-specific protease 36 is an enzyme that in humans is encoded by the USP36 gene. This gene encodes a member of the ubiquitin-specific protease family of proteases that is a deubiquitinating enzyme (DUB) with His and Cys domains. This protein is located in the nucleoli and deubuquitinate nucleophosmin and fibrillarin. May be required for maintaining multiple types of adult stem cells. May function as a transcriptional repressor by continually deubiquiting histone H2B at the promoters of genes critical for cellular differentiation, thereby preventing histone H3 'Lys-4' trimethylation (H3K4).