Lane 1: NIH/3T3
Lane 2: C2C12
Recombinant Rabbit monoclonal primary
TWEAKR Recombinant Rabbit Monoclonal Antibody [SN20-07] (ET1611-93)
NIH/3T3, C2C12, mouse uterus tissue.
Store at +4C after thawing. Aliquot store at -20C or -80C. Avoid repeated freeze / thaw cycles.
1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Protein A purified.
CD 266 antibody; CD266 antibody; CD266 antigen antibody; FGF inducible 14 antibody; FGF-inducible 14 antibody; Fibroblast growth factor inducible immediate early response protein 14 antibody; Fibroblast growth factor-inducible immediate-early response protein 14 antibody; FN 14 antibody; FN14 antibody; TNFRSF 12A antibody; TNFRSF12A antibody; TNR12_HUMAN antibody; Tumor necrosis factor receptor superfamily member 12A antibody; TWEAK R antibody; Tweak receptor antibody; Tweak-receptor antibody; TweakR antibody
Highly expressed in heart, placenta and kidney. Intermediate expression in lung, skeletal muscle and pancreas.
Fn14, the TWEAK receptor, is a recently identified member of the TNF receptor superfamily and is expressed on smooth muscle cells and endothelial cells. It is a weak inducer of apoptosis and promotes angiogenesis. Fn14 is a type 1 membrane protein. It associates with TRAF1 and TRAF2, and may modulate cellular adhesion to matrix proteins. Fn14 is highly expressed in heart, placenta and kidney, and moderately expressed in lung, skeletal muscle and pancreas. It is the smallest member of the TNF receptor (TNFR) superfamily described to date, and signals via recruitment of several different TNFR-associated factors.