TWEAKR Recombinant Rabbit Monoclonal Antibody [SN20-07] (ET1611-93)
Catalog# ET1611-93
Rabbit Monoclonal to TWEAKR
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WB
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IHC-P
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IP
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Human
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Mouse
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Rat
Positive control:
Lane 1: NIH/3T3 cell lysates
Lane 2: C2C12 cell lysates
Specifications
Product Type
Recombinant Rabbit monoclonal primary
Product Name
TWEAKR Recombinant Rabbit Monoclonal Antibody [SN20-07] (ET1611-93)
Immunogen
Synthetic peptide within human tweakr aa 80-129 / 129.
Host
Rabbit
Positive Control
NIH/3T3 cell lysates , C2C12 cell lysates, mouse uterus tissue.
Conjugation
Unconjugated
Clonality
Monoclonal
Clone Number
SN20-07
RRID
APPLICATION DILUTION
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WB
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1:500-1:1,000
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IHC-P
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1:50-1:200
PROPERTIES
Form
Liquid
Storage Condition
Store at +4C after thawing. Aliquot store at -20C or -80C. Avoid repeated freeze / thaw cycles.
Storage Buffer
1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Concentration
1ug/ul
Purification
Protein A affinity purified.
Molecular Weight
14 kDa
Isotype
IgG
TARGET
UNIPROT #
PROTEIN NAME
TWEAKR
SYNONYMS
CD 266 antibody;CD266 antibody;CD266 antigen antibody;FGF inducible 14 antibody;FGF-inducible 14 antibody;Fibroblast growth factor inducible immediate early response protein 14 antibody;Fibroblast growth factor-inducible immediate-early response protein 14 antibody;FN 14 antibody;FN14 antibody;TNFRSF 12A antibody;TNFRSF12A antibody;TNR12_HUMAN antibody;Tumor necrosis factor receptor superfamily member 12A antibody;TWEAK R antibody;Tweak receptor antibody;Tweak-receptor antibody;TweakR antibody
TISSUE SPECIFICITY
Highly expressed in heart, placenta and kidney. Intermediate expression in lung, skeletal muscle and pancreas.
SUBCELLULAR LOCATION
Membrane.
FUNCTION
Fn14, the TWEAK receptor, is a recently identified member of the TNF receptor superfamily and is expressed on smooth muscle cells and endothelial cells. It is a weak inducer of apoptosis and promotes angiogenesis. Fn14 is a type 1 membrane protein. It associates with TRAF1 and TRAF2, and may modulate cellular adhesion to matrix proteins. Fn14 is highly expressed in heart, placenta and kidney, and moderately expressed in lung, skeletal muscle and pancreas. It is the smallest member of the TNF receptor (TNFR) superfamily described to date, and signals via recruitment of several different TNFR-associated factors.
CITATIONS
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J Qian,et al
The CD163/TWEAK/Fn14 axis: A potential therapeutic target for alleviating inflammatory bone loss
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IHC
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Mouse
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Citation
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