Lane 1: Mouse lung tissue lysate
Lane 2: Rat lung tissue lysate
Rabbit polyclonal primary
TTF-1 Antibody (ER1902-68)
Synthetic peptide corresponding to c terminal human ttf-1 .
Mouse lung tissue lysate, rat lung tissue lysate.
Store at +4C after thawing. Aliquot store at -20C. Avoid repeated freeze / thaw cycles.
1*PBS (pH7.4), 0.2% BSA, 50% Glycerol. Preservative: 0.05% Sodium Azide.
Peptide affinity purified.
Predicted band size 42/39 kDa.
Homeobox protein Nkx-2.1
Homeobox protein Nkx-2.1,Homeobox protein NK-2 homolog A Thyroid nuclear factor 1 Thyroid transcription factor 1 TTF-1 Thyroid-specific enhancer-binding protein T/EBP NKX2-1
Belongs to the NK-2 homeobox family.
Thyroid and lung.
Phosphorylated on serine residues by STK3/MST2.
Transcription factor that binds and activates the promoter of thyroid specific genes such as thyroglobulin, thyroperoxidase, and thyrotropin receptor. Crucial in the maintenance of the thyroid differentiation phenotype. May play a role in lung development and surfactant homeostasis. Forms a regulatory loop with GRHL2 that coordinates lung epithelial cell morphogenesis and differentiation. Activates the transcription of GNRHR and plays a role in enhancing the circadian oscillation of its gene expression. Represses the transcription of the circadian transcriptional repressor NR1D1 (By similarity).