TrkA Recombinant Rabbit Monoclonal Antibody [JJ084-04] (ET1608-44)

UNIPROT #

P04629

PROTEIN NAME

TrkA

SYNONYMS

gp140trk antibody;High affinity nerve growth factor receptor antibody;High affinity nerve growth factor receptor precursor antibody;MTC antibody;Neurotrophic tyrosine kinase receptor type 1 antibody;NTRK1 antibody;NTRK1_HUMAN antibody;Oncogene TRK antibody;p14-TrkA antibody;p140 TrkA antibody;p140-TrkA antibody;Slow nerve growth antibody;Trk A antibody;TRK antibody;Trk-A antibody;TRK1 antibody;TRK1-transforming tyrosine kinase protein antibody;Tropomyosin-related kinase A antibody;Tyrosine kinase receptor A antibody;Tyrosine kinase receptor antibody

SEQUENCE SIMILARITIES

Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily.

TISSUE SPECIFICITY

Isoform TrkA-I is found in most non-neuronal tissues. Isoform TrkA-II is primarily expressed in neuronal cells. TrkA-III is specifically expressed by pluripotent neural stem and neural crest progenitors.

POST-TRANSLATIONAL MODIFICATION

Ligand-mediated autophosphorylation. Interaction with SQSTM1 is phosphotyrosine-dependent. Autophosphorylation at Tyr-496 mediates interaction and phosphorylation of SHC1.; N-glycosylated. Isoform TrkA-I and isoform TrkA-II are N-glycosylated.; Ubiquitinated. Undergoes polyubiquitination upon activation; regulated by NGFR. Ubiquitination by NEDD4L leads to degradation. Ubiquitination regulates the internalization of the receptor (By similarity).

SUBCELLULAR LOCATION

Cell membrane, Early endosome membrane, Late endosome membrane.

FUNCTION

Tropomyosin receptor kinase A (TrkA), also known as high affinity nerve growth factor receptor, neurotrophic tyrosine kinase receptor type 1, or TRK1-transforming tyrosine kinase protein. This gene encodes a member of the neurotrophic tyrosine kinase receptor (NTKR) family. This kinase is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself (autophosphorylation) and members of the MAPK pathway. The presence of this kinase leads to cell differentiation and may play a role in specifying sensory neuron subtypes. Mutations in this gene have been associated with congenital insensitivity to pain with anhidrosis, self-mutilating behaviors, intellectual disability and/or cognitive impairment and certain cancers.