Positive control:
Lane 1: Raji
Lane 2: Daudi
Lane 3: Jurkat
Lane 4: THP-1
Applications
-
WB
-
IHC-P
REACTIVITY
-
Human
-
Mouse
-
Rat
SPECIFICATIONS
Product Type
Rabbit polyclonal primary
Product Name
TLR7 Antibody (ER30606)
Immunogen
Peptide
Host
Rabbit
Positive Control
Raji, Daudi, Jurkat, THP-1, human tonsil tissue, human lung tissue, mouse lung tissue.
Conjugation
Unconjugated
Clonality
Polyclonal
PROPERTIES
Form
Liquid
Storage Condition
Store at +4C after thawing. Aliquot store at -20C or -80C. Avoid repeated freeze / thaw cycles.
Storage Buffer
1*PBS (pH7.4), 0.2% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Concentration
1 ug/ul
PURIFICATION
Peptide affinity purified
MOLECULAR WEIGHT
140 kDa
Isotype
IgG
APPLICATION DILUTION
-
WB
-
1:1,000
-
IHC-P
-
1:200
TARGET
UNIPROT #
PROTEIN NAME
TLR7
SYNONYMS
PRO285 antibody; TLR 7 antibody; Tlr7 antibody; TLR7_HUMAN antibody; Toll like receptor 7 antibody; Toll-like receptor 7 antibody; UNQ248 antibody
SEQUENCE SIMILARITIES
Belongs to the Toll-like receptor family.
TISSUE SPECIFICITY
Detected in brain, placenta, spleen, stomach, small intestine, lung and in plasmacytoid pre-dendritic cells.
SUBCELLULAR LOCATION
Endoplasmic reticulum membrane.
FUNCTION
Members of the Toll-like receptor (TLR) family, named for the closely related Toll receptor in Drosophila, play a pivotal role in innate immune responses. TLRs recognize conserved motifs found in various pathogens and mediate defense responses. TLR7, 8 and 9 form a group of structurally related TLR family members that are localized to intracellular endosomes . TLR7 shows highest expression in lung, placenta, and spleen. TLR7 mediates responses to a class of synthetic compounds, including imidazoquinolines, guanosine-based drugs that induce anti-viral responses.