Lane 1: Raji
Lane 2: Daudi
Lane 3: Jurkat
Lane 4: THP-1
Rabbit polyclonal primary
TLR7 Antibody (ER30606)
Raji, Daudi, Jurkat, THP-1, human tonsil tissue, human lung tissue, mouse lung tissue.
Store at +4C after thawing. Aliquot store at -20C or -80C. Avoid repeated freeze / thaw cycles.
1*PBS (pH7.4), 0.2% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Peptide affinity purified
PRO285 antibody; TLR 7 antibody; Tlr7 antibody; TLR7_HUMAN antibody; Toll like receptor 7 antibody; Toll-like receptor 7 antibody; UNQ248 antibody
Belongs to the Toll-like receptor family.
Detected in brain, placenta, spleen, stomach, small intestine, lung and in plasmacytoid pre-dendritic cells.
Endoplasmic reticulum membrane.
Members of the Toll-like receptor (TLR) family, named for the closely related Toll receptor in Drosophila, play a pivotal role in innate immune responses. TLRs recognize conserved motifs found in various pathogens and mediate defense responses. TLR7, 8 and 9 form a group of structurally related TLR family members that are localized to intracellular endosomes . TLR7 shows highest expression in lung, placenta, and spleen. TLR7 mediates responses to a class of synthetic compounds, including imidazoquinolines, guanosine-based drugs that induce anti-viral responses.