Lane 1: Hela
Lane 2: Human lung tissue
Lane 3: Human placenta tissue
Lane 4: HepG2
Rabbit polyclonal primary
TEAD4 Antibody (ER1706-98)
Hela, human lung tissue lysate, human placenta tissue lysate, HepG2, LOVO.
Store at +4C after thawing. Aliquot store at -20C or -80C. Avoid repeated freeze / thaw cycles.
1*PBS (pH7.4), 0.2% BSA, 50% Glycerol. Preservative: 0.05% Sodium Azide.
Peptide affinity purified
Transcriptional enhancer factor TEF-3
TEAD-4, TEAD4, RTEF1, TCF13L1, TEF3
Preferentially expressed in skeletal muscle. Lower levels in pancreas, placenta, and heart.
Transcription factor which plays a key role in the Hippo signaling pathway, a pathway involved in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein MST1/MST2, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Acts by mediating gene expression of YAP1 and WWTR1/TAZ, thereby regulating cell proliferation, migration and epithelial mesenchymal transition (EMT) induction. Binds specifically and non-cooperatively to the Sph and GT-IIC 'enhansons' (5'-GTGGAATGT-3') and activates transcription. Binds to the M-CAT motif.