Lane 1: mouse skeletal muscle tissue lysate
Lane 2: rat skeletal muscle tissue lysate
Rabbit polyclonal primary
Syntrophin alpha 1 Rabbit Polyclonal Antibody (ER1901-45)
Synthetic peptide within mouse syntrophin alpha 1 aa 174-223 / 503.
Mouse skeletal muscle tissue lysate, rat skeletal muscle tissue lysate, SW620, human kidney tissue, mouse skeletal muscle tissue, SiHa.
Store at +4C after thawing. Aliquot store at -20C. Avoid repeated freeze / thaw cycles.
1*PBS (pH7.4), 0.2% BSA, 50% Glycerol. Preservative: 0.05% Sodium Azide.
Peptide affinity purified.
Syntrophin alpha 1
59 kDa dystrophin-associated protein A1 acidic component 1 antibody; Alpha-1-syntrophin antibody; Pro-TGF-alpha cytoplasmic domain-interacting protein 1 antibody; SNT1 antibody; SNT2 antibody; SNT3 antibody; Snta1 antibody; SNTA1_HUMAN antibody; SNTB1 antibody; SNTB2 antibody; Syntrophin alpha 1 antibody; Syntrophin beta 1 antibody; Syntrophin beta 2 antibody; Syntrophin-1 antibody; TACIP1 antibody
Belongs to the syntrophin family.
High expression in skeletal muscle and heart. Low expression in brain, pancreas, liver, kidney and lung. Not detected in placenta.
Phosphorylated by CaM-kinase II. Phosphorylation may inhibit the interaction with DMD (By similarity).
Sarcolemma, cytoskeleton, cell junction.
Syntrophins are cytoplasmic peripheral membrane scaffold proteins that are components of the dystrophin-associated protein complex. This gene is a member of the syntrophin gene family and encodes the most common syntrophin isoform found in cardiac tissues. The N-terminal PDZ domain of this syntrophin protein interacts with the C-terminus of the pore-forming alpha subunit (SCN5A) of the cardiac sodium channel Nav1.5. This protein also associates cardiac sodium channels with the nitric oxide synthase-PMCA4b (plasma membrane Ca-ATPase subtype 4b) complex in cardiomyocytes. This gene is a susceptibility locus for Long-QT syndrome (LQT) - an inherited disorder associated with sudden cardiac death from arrhythmia - and sudden infant death syndrome (SIDS). This protein also associates with dystrophin and dystrophin-related proteins at the neuromuscular junction and alters intracellular calcium ion levels in muscle tissue.