Lane 1: K562 cell lysate
Lane 2: Mouse brain tissue lysate
Rabbit polyclonal primary
SynGAP Antibody (ER1902-57)
Recombinant protein within human syngap aa 1100-1250.
K562 cell lysate, mouse brain tissue lysate, human terus tissue, mouse brain tissue, SW620.
Store at +4C after thawing. Aliquot store at -20C. Avoid repeated freeze / thaw cycles.
1*PBS (pH7.4), 0.2% BSA, 50% Glycerol. Preservative: 0.05% Sodium Azide.
Protein affinity purified.
Ras/Rap GTPase-activating protein SynGAP
Ras/Rap GTPase-activating protein SynGAP,Neuronal RasGAP,Synaptic Ras GTPase-activating protein 1, Synaptic Ras-GAP 1,YNGAP1
Phosphorylated by CaM-kinase II. Dephosphorylated upon NMDA receptor activation or SYNGAP1/MPDZ complex disruption. Phosphorylation by PLK2 promotes its activity (By similarity).
Major constituent of the PSD essential for postsynaptic signaling. Inhibitory regulator of the Ras-cAMP pathway. Member of the NMDAR signaling complex in excitatory synapses, it may play a role in NMDAR-dependent control of AMPAR potentiation, AMPAR membrane trafficking and synaptic plasticity. Regulates AMPAR-mediated miniature excitatory postsynaptic currents. Exhibits dual GTPase-activating specificity for Ras and Rap. May be involved in certain forms of brain injury, leading to long-term learning and memory deficits (By similarity).