Slit2 Recombinant Rabbit Monoclonal Antibody [JE31-87] (HA721407)

UNIPROT #

O94813

PROTEIN NAME

Slit2

SYNONYMS

Drad 1 antibody;E030015M03Rik antibody;E130320P19Rik antibody;FLJ14420 antibody;OTTHUMP00000158695 antibody;OTTHUMP00000217852 antibody;OTTHUMP00000217853 antibody;OTTHUMP00000217854 antibody;Slil 3 antibody;Slil3 antibody;Slit 2 antibody;Slit homolog 2 (Drosophila) antibody;Slit homolog 2 antibody;Slit homolog 2 protein antibody;Slit homolog 2 protein C-product antibody;Slit-2 antibody;Slit2 antibody;SLIT2_HUMAN antibody

SUBCELLULAR LOCATION

Secreted.

FUNCTION

SLIT2 thought to act as molecular guidance cue in cellular migration, and function appears to be mediated by interaction with roundabout homolog receptors. During neural development involved in axonal navigation at the ventral midline of the neural tube and projection of axons to different regions. SLIT1 and SLIT2 seem to be essential for midline guidance in the forebrain by acting as repulsive signal preventing inappropriate midline crossing by axons projecting from the olfactory bulb. In spinal cord development may play a role in guiding commissural axons once they reached the floor plate by modulating the response to netrin. In vitro, silences the attractive effect of NTN1 but not its growth-stimulatory effect and silencing requires the formation of a ROBO1-DCC complex. May be implicated in spinal cord midline post-crossing axon repulsion. In vitro, only commissural axons that crossed the midline responded to SLIT2. In the developing visual system appears to function as repellent for retinal ganglion axons by providing a repulsion that directs these axons along their appropriate paths prior to, and after passage through, the optic chiasm. In vitro, collapses and repels retinal ganglion cell growth cones. Seems to play a role in branching and arborization of CNS sensory axons, and in neuronal cell migration. In vitro, Slit homolog 2 protein N-product, but not Slit homolog 2 protein C-product, repels olfactory bulb (OB) but not dorsal root ganglia (DRG) axons, induces OB growth cones collapse and induces branching of DRG axons. Seems to be involved in regulating leukocyte migration.