Applications
-
WB
-
IF
-
IHC-P
REACTIVITY
-
Zebrafish
SPECIFICATIONS
Product Type
Rabbit polyclonal primary
Product Name
SEL1L Antibody (ER1803-69)
Immunogen
Recombinant protein within zebrafish sel1l aa 100-300.
Host
Rabbit
Positive Control
Zebrafish.
Conjugation
Unconjugated
Clonality
Polyclonal
PROPERTIES
Form
Liquid
Storage Condition
Store at +4C after thawing. Aliquot store at -20C. Avoid repeated freeze / thaw cycles.
Storage Buffer
1*PBS (pH7.4), 0.2% BSA, 50% Glycerol. Preservative: 0.05% Sodium Azide.
Concentration
1 ug/ul
PURIFICATION
Protein affinity purified.
MOLECULAR WEIGHT
85 kDa
Isotype
IgG
APPLICATION DILUTION
-
WB
-
1:500
-
IF:1:50-1:200
-
IHC-P:1:200
TARGET
UNIPROT #
PROTEIN NAME
SEL1L
SYNONYMS
IBD2 antibody; PRO1063 antibody; Protein sel-1 homolog 1 antibody; SE1L1_HUMAN antibody; Sel 1 like protein antibody; Sel 1 suppressor of lin 12 like antibody; Sel-1L antibody; SEL1 LIKE antibody; Sel1l antibody; SEL1LIKE antibody; Suppressor of lin-12-like protein 1 antibody; TSA305 antibody; UNQ128 antibody; UNQ128/PRO1063 antibody
SUBCELLULAR LOCATION
Cytoplasm.
FUNCTION
Protein sel-1 homolog 1 is a protein that in humans is encoded by the SEL1L gene. May play a role in Notch signaling. May be involved in the endoplasmic reticulum quality control (ERQC) system also called ER-associated degradation (ERAD) involved in ubiquitin-dependent degradation of misfolded endoplasmic reticulum proteins. In mammals, the most well-characterized ERAD machinery is the highly conserved complex of suppressor-enhancer of lin-12–like and hydroxymethylglutaryl-CoA reductase degradation protein 1 (SEL1L-HRD1), which consists of the E3 ubiquitin ligase HRD1 and its adaptor protein SEL1Lc.The Sel1L-deficient experimental model of central diabetes insipidus is unlikely to be observed in humans, as Sel1L loss is embryonically lethal. Three-week-old mice with Sel1L deficiency specifically in AVP neurons (Sel1LAVP mice) lacked AVP-positive transport vesicles in axons, a phenotype that explains the development of the central diabetes insipidus phenotype in these mice.