UNIPROT #

P51170

PROTEIN NAME

Amiloride-sensitive sodium channel subunit gamma

GENE NAME

SCNN1G

SYNONYMS

ENaCG, Gamma-ENaC, SCNN1G

SEQUENCE SIMILARITIES

Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family. SCNN1G subfamily.

TISSUE SPECIFICITY

Expressed in kidney (at protein level).

POST-TRANSLATIONAL MODIFICATION

Phosphorylated on serine and threonine residues. Aldosterone and insulin increase the basal level of phosphorylation.; Ubiquitinated; this targets individual subunits for endocytosis and proteasome-mediated degradation.; ENaC cleavage by furin, and subsequently by prostasin (PRSS8), leads to a stepwise increase in the open probability of the channel as a result of release of the alpha and gamma subunit inhibitory tracts, respectively. Interaction of ENaC subunit SCNN1B with BPIFA1 protects ENaC against proteolytic activation.

SUBCELLULAR LOCATION

Apical cell membrane; Multi-pass membrane protein.

FUNCTION

Sodium permeable non-voltage-sensitive ion channel inhibited by the diuretic amiloride. Mediates the electrodiffusion of the luminal sodium (and water, which follows osmotically) through the apical membrane of epithelial cells. Plays an essential role in electrolyte and blood pressure homeostasis, but also in airway surface liquid homeostasis, which is important for proper clearance of mucus. Controls the reabsorption of sodium in kidney, colon, lung and sweat glands. Also plays a role in taste perception.