Rabbit polyclonal primary
SCNN1G Antibody (ER1803-61)
Recombinant protein within human scnn1g aa 250-350.
A431, 293T, rat kidney tissue, mouse brain tissue.
Store at +4C after thawing. Aliquot store at -20C. Avoid repeated freeze / thaw cycles.
1*PBS (pH7.4), 0.2% BSA, 50% Glycerol. Preservative: 0.05% Sodium Azide.
Protein affinity purified.
Amiloride-sensitive sodium channel subunit gamma
ENaCG, Gamma-ENaC, SCNN1G
Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family. SCNN1G subfamily.
Expressed in kidney (at protein level).
Phosphorylated on serine and threonine residues. Aldosterone and insulin increase the basal level of phosphorylation.; Ubiquitinated; this targets individual subunits for endocytosis and proteasome-mediated degradation.; ENaC cleavage by furin, and subsequently by prostasin (PRSS8), leads to a stepwise increase in the open probability of the channel as a result of release of the alpha and gamma subunit inhibitory tracts, respectively. Interaction of ENaC subunit SCNN1B with BPIFA1 protects ENaC against proteolytic activation.
Apical cell membrane; Multi-pass membrane protein.
Sodium permeable non-voltage-sensitive ion channel inhibited by the diuretic amiloride. Mediates the electrodiffusion of the luminal sodium (and water, which follows osmotically) through the apical membrane of epithelial cells. Plays an essential role in electrolyte and blood pressure homeostasis, but also in airway surface liquid homeostasis, which is important for proper clearance of mucus. Controls the reabsorption of sodium in kidney, colon, lung and sweat glands. Also plays a role in taste perception.