Rabbit polyclonal primary
RYR1 Antibody (ER1803-19)
Synthetic peptide within human ryr1 aa 1350-1400.
Human fetal skeletal muscle tissue, mouse cerebellum tissue, SiHa.
Store at +4C after thawing. Aliquot store at -20C. Avoid repeated freeze / thaw cycles.
1*PBS (pH7.4), 0.2% BSA, 50% Glycerol. Preservative: 0.05% Sodium Azide.
Peptide affinity purified.
Arrhythmogenic right ventricular dysplasia 2 antibody; ARVC2 antibody; ARVD2 antibody; Brain ryanodine receptor calcium release channel antibody; Brain type ryanodine receptor antibody; Cardiac muscle ryanodine receptor calcium release channel antibody; Cardiac muscle type ryanodine receptor antibody; CCO antibody; Central core disease of muscle antibody; HBRR antibody; hRYR 2 antibody; hRYR2 antibody; MHS antibody; MHS1 antibody; Ryanodine receptor 1 (skeletal) antibody; Ryanodine receptor 1 antibody; Ryanodine receptor 2 (cardiac) antibody; Ryanodine receptor 2 antibody; Ryanodine receptor 3 antibody; Ryanodine receptor type1 antibody; RYDR antibody; RYR 1 antibody; RYR 2 antibody; RYR 3 antibody; RYR antibody; RYR-1 antibody; RyR1 antibody; RYR1_HUMAN antibody; RYR2 antibody; RYR3 antibody; Sarcoplasmic reticulum calcium release channel antibody; Skeletal muscle calcium release channel antibody; Skeletal muscle ryanodine receptor antibody; Skeletal muscle type ryanodine receptor antibody; Skeletal muscle-type ryanodine receptor antibody; SKRR antibody; Type 1 like ryanodine receptor antibody; Type 1 ryanodine receptor antibody; VTSIP antibody
Belongs to the ryanodine receptor (TC 1.A.3.1) family. RYR1 subfamily.
Skeletal muscle and brain (cerebellum and hippocampus).
Channel activity is modulated by phosphorylation. Phosphorylation at Ser-2843 may increase channel activity. Repeated very high-level exercise increases phosphorylation at Ser-2843.; Activated by reversible S-nitrosylation (By similarity). Repeated very high-level exercise increases S-nitrosylation.
Sarcoplasmic reticulum membrane.
Calcium channel that mediates the release of Ca2+ from the sarcoplasmic reticulum into the cytoplasm and thereby plays a key role in triggering muscle contraction following depolarization of T-tubules. Repeated very high-level exercise increases the open probability of the channel and leads to Ca2+ leaking into the cytoplasm. Can also mediate the release of Ca2+ from intracellular stores in neurons, and may thereby promote prolonged Ca2+ signaling in the brain. Required for normal embryonic development of muscle fibers and skeletal muscle. Required for normal heart morphogenesis, skin development and ossification during embryogenesis.