PRODUCT CODE: ET1701-78

Recombinant ZNRF2 Monoclonal Antibody (ET1701-78)

  • Recombinant

Applications

  • WB

  • IHC-P

REACTIVITY

  • Human

  • Mouse

  • Rat

Immunohistochemical analysis of paraffin-embedded mouse testis tissue using anti-ZNRF2 antibody. Counter stained with hematoxylin.
  • Immunohistochemical analysis of paraffin-embedded mouse testis tissue using anti-ZNRF2 antibody. Counter stained with hematoxylin.
Immunohistochemical analysis of paraffin-embedded mouse testis tissue using anti-ZNRF2 antibody. Counter stained with hematoxylin.

Applications

  • WB

  • IHC-P

REACTIVITY

  • Human

  • Mouse

  • Rat

SPECIFICATIONS

Product Type

Recombinant Rabbit monoclonal primary

Product Name

Recombinant ZNRF2 Monoclonal Antibody (ET1701-78)

Immunogen

Recombinant protein

Host

Rabbit

Positive Control

Mouse testis tissue.

Conjugation

Unconjugated

Clonality

Monoclonal

Clone Number

JJ0924

PROPERTIES

Form

Liquid

Storage Condition

Store at +4C after thawing. Aliquot store at -20C or -80C. Avoid repeated freeze / thaw cycles.

Storage Buffer

1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.

Concentration

1 ug/ul

PURIFICATION

Protein A purified.

MOLECULAR WEIGHT

24 kDa

Isotype

IgG

APPLICATION DILUTION

  • WB

  • 1:1,000-1:2,000

  • IHC-P

  • 1:50-1:200

TARGET

UNIPROT #

PROTEIN NAME

ZNRF2

SYNONYMS

E3 ubiquitin-protein ligase ZNRF2 antibody; Protein Ells2 antibody; RING finger protein 202 antibody; RNF202 antibody; Zinc/RING finger protein 2 antibody; Znrf2 antibody; ZNRF2_HUMAN antibody

TISSUE SPECIFICITY

Highly expressed in the brain, with higher expression during development than in adult. Expressed also in mammary glands, testis, colon and kidney.

SUBCELLULAR LOCATION

Endosome membrane, Lysosome membrane, Cell junction.

FUNCTION

NF-E2 related factor 2 (Nrf2) is a member of the cap ‘n’ collar family of basic leucine zipper transcription factors. By binding antioxidant response elements (AREs), Nrf2 activates the transcription of genes encoding antioxidant and phase II drug-metabolizing enzymes needed to protect cells against oxidative damage. Transcriptional targets regulated by Nrf2 include genes encoding glutathione S-transferases, superoxide dismutase-1, and heme oxygenase-1.