UNIPROT #

Q15915

PROTEIN NAME

Zic1

SYNONYMS

Odd paired homolog Drosophila antibody; Zic 1 antibody; ZIC antibody; Zic family member 1 (odd-paired Drosophila homolog) antibody; Zic family member 1 antibody; Zic protein member 1 antibody; zic1 antibody; ZIC1_HUMAN antibody; Zinc finger protein 201 antibody; Zinc finger protein of the cerebellum 1 antibody; Zinc finger protein ZIC 1 antibody; Zinc finger protein ZIC1 antibody; ZNF 201 antibody; ZNF201 antibody

SEQUENCE SIMILARITIES

Belongs to the GLI C2H2-type zinc-finger protein family.

TISSUE SPECIFICITY

CNS. A high level expression is seen in the cerebellum. Detected in the nuclei of the cerebellar granule cell lineage from the progenitor cells of the external germinal layer to the postmigrated cells of the internal granular layer. Detected in medulloblastoma (26/29 cases), but not present in all other tumors examined.

SUBCELLULAR LOCATION

Nucleus. Cytoplasm.

FUNCTION

Zic1 (zinc finger protein of the cerebellum 1) is a C2H2 zinc finger transcription factor that controls the expansion of neuronal precursors by inhibiting the progression of neuronal differentiation. Zic1 determines the cerebellar folial pattern by influencing proliferation in the external germinal layer (EGL). Zic1 can bind and transactivate the apolipoprotein E gene.This gene is closely linked to the gene encoding zinc finger protein of the cerebellum 4, a related family member on chromosome 3.