PRODUCT CODE: ET7107-21

Recombinant VPS26 Monoclonal Antibody (ET7107-21)

  • Recombinant

Applications

  • WB

  • IHC-P

  • IP

REACTIVITY

  • Human

  • Mouse

  • Rat

-
+
Western blot analysis of VPS26 on different cell lysates using anti-VPS26 at 1/500 dilution.<br />
  Positive control:<br />
  Line 1: Rat kidney tissue <br />
  Line 2: A431
  • Western blot analysis of VPS26 on different cell lysates using anti-VPS26 at 1/500 dilution.<br />
  Positive control:<br />
  Line 1: Rat kidney tissue <br />
  Line 2: A431
  • Immunohistochemical analysis of paraffin-embedded rat kidney tissue using anti-VPS26 antibody. Counter stained with hematoxylin.
  • Immunohistochemical analysis of paraffin-embedded human tonsil tissue using anti-VPS26 antibody. Counter stained with hematoxylin.
  • Immunohistochemical analysis of paraffin-embedded mouse testis tissue using anti-VPS26 antibody. Counter stained with hematoxylin.
Western blot analysis of VPS26 on different cell lysates using anti-VPS26 at 1/500 dilution.
Positive control:
Line 1: Rat kidney tissue
Line 2: A431

Applications

  • WB

  • IHC-P

  • IP

REACTIVITY

  • Human

  • Mouse

  • Rat

SPECIFICATIONS

Product Type

Recombinant Rabbit monoclonal primary

Product Name

Recombinant VPS26 Monoclonal Antibody (ET7107-21)

Immunogen

Recombinant protein

Host

Rabbit

Positive Control

Rat kidney tissue , A431, human tonsil tissue, rat kidney tissue, mouse testis tissue.

Conjugation

Unconjugated

Clonality

Monoclonal

Clone Number

JB93-41

PROPERTIES

Form

Liquid

Storage Condition

Store at +4C after thawing. Aliquot store at -20C or -80C. Avoid repeated freeze / thaw cycles.

Storage Buffer

1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.

Concentration

1 ug/ul

PURIFICATION

Protein A purified.

MOLECULAR WEIGHT

38 kDa

Isotype

IgG

APPLICATION DILUTION

  • WB

  • 1:500-1:2,000

  • IHC-P

  • 1:50-1:200

  • IP

  • 1:10-1:50

TARGET

UNIPROT #

PROTEIN NAME

VPS26

SYNONYMS

FLJ12930 antibody; HB 58 antibody; HB58 antibody; Hbeta 58 antibody; Hbeta 58 homolog antibody; Hbeta58 antibody; Hbeta58 homolog antibody; hVPS 26 antibody; hVPS26 antibody; MGC94168 antibody; PEP 8A antibody; PEP8A antibody; Vacuolar protein sorting 26 A antibody; Vacuolar protein sorting 26 antibody; Vacuolar protein sorting 26 homolog A antibody; Vacuolar protein sorting 26 homolog A S. pombe antibody; Vacuolar protein sorting 26 homolog A yeast antibody; Vacuolar protein sorting 26 yeast antibody; Vacuolar protein sorting 26 yeast homolog antibody; Vacuolar protein sorting 26A antibody; Vacuolar protein sorting associated protein 26A antibody; Vacuolar protein sorting-associated protein 26A antibody; Vesicle protein sorting 26 antibody; Vesicle protein sorting 26A antibody; VP26A_HUMAN antibody; VPS 26 antibody; VPS 26A antibody; VPS26A antibody

SEQUENCE SIMILARITIES

Belongs to the VPS26 family.

SUBCELLULAR LOCATION

Endosome. Cytoplasm.

FUNCTION

Acts as component of the retromer cargo-selective complex (CSC). The CSC is believed to be the core functional component of retromer or respective retromer complex variants acting to prevent missorting of selected transmembrane cargo proteins into the lysosomal degradation pathway. The recruitment of the CSC to the endosomal membrane involves RAB7A and SNX3. The SNX-BAR retromer mediates retrograde transport of cargo proteins from endosomes to the trans-Golgi network (TGN) and is involved in endosome-to-plasma membrane transport for cargo protein recycling. The SNX3-retromer mediates the retrograde endosome-to-TGN transport of WLS distinct from the SNX-BAR retromer pathway. Required for retrograde transport of lysosomal enzyme receptor IGF2R. Required to regulate transcytosis of the polymeric immunoglobulin receptor (pIgR-pIgA). Required for the endosomal localization of WASHC2A (indicative for the WASH complex). Required for the endosomal localization of TBC1D5. Mediates retromer cargo recognition of SORL1 and is involved in trafficking of SORL1 implicated in sorting and processing of APP. Involved in retromer-independent lysosomal sorting of F2R. Involved in recycling of ADRB2. Enhances the affinity of SNX27 for PDZ-binding motifs in cargo proteins.