Lane 1: Human liver
Lane 2: Human serum
Recombinant Rabbit monoclonal primary
Recombinant Vitronectin Monoclonal Antibody (ET1609-39)
A431, A549, MCF-7, HepG2, mouse liver tissue, mouse skin tissue, human liver tissue, human liver cancer tissue.
Store at +4C after thawing. Aliquot store at -20C or -80C. Avoid repeated freeze / thaw cycles.
1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Protein A purified.
Expressed in the retina pigment epithelium (at protein level). Expressed in plasma (at protein level). Expressed in serum (at protein level).
Sulfated on tyrosine residues.; N- and O-glycosylated.; Phosphorylation on Thr-69 and Thr-76 favors cell adhesion and spreading.; It has been suggested that the active SMB domain may be permitted considerable disulfide bond heterogeneity or variability, thus two alternate disulfide patterns based on 3D structures are described with 1 disulfide bond conserved in both.; Phosphorylation sites are present in the extracellular medium.
Secreted, extracellular space.; Parasitophorous vacuole. Note=(Microbial infection) In P.falciparum-infected red blood cells, VTN internalization is detected at the early trophozoite stage. Colocalizes with SERA5 at the schizont stage and with SERA5 P47 at the merozoite surface.
Vitronectin is a cell adhesion and spreading factor found in serum and tissues. Vitronectin interact with glycosaminoglycans and proteoglycans. Is recognized by certain members of the integrin family and serves as a cell-to-substrate adhesion molecule. Inhibitor of the membrane-damaging effect of the terminal cytolytic complement pathway.; Somatomedin-B is a growth hormone-dependent serum factor with protease-inhibiting activity.