Recombinant Rabbit monoclonal primary
Recombinant Usp14 Monoclonal Antibody (ET1706-37)
K562, Hela, Zebrafish tissue lysates, A431, HUVEC, LOVO, Jurkat, human colon cancer tissue, human kidney tissue, mouse prostate tissue, rat epididymis tissue.
Store at +4C after thawing. Aliquot store at -20C or -80C. Avoid repeated freeze / thaw cycles.
1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Protein A purified.
Ubiquitin carboxyl-terminal hydrolase 14
Belongs to the peptidase C19 family. USP14/UBP6 subfamily.
Cytoplasm. Cell membrane; Peripheral membrane protein.
Proteasome-associated deubiquitinase which releases ubiquitin from the proteasome targeted ubiquitinated proteins. Ensures the regeneration of ubiquitin at the proteasome. Is a reversibly associated subunit of the proteasome and a large fraction of proteasome-free protein exists within the cell. Required for the degradation of the chemokine receptor CXCR4 which is critical for CXCL12-induced cell chemotaxis. Serves also as a physiological inhibitor of endoplasmic reticulum-associated degradation (ERAD) under the non-stressed condition by inhibiting the degradation of unfolded endoplasmic reticulum proteins via interaction with ERN1. Indispensable for synaptic development and function at neuromuscular junctions (NMJs). Plays a role in the innate immune defense against viruses by stabilizing the viral DNA sensor CGAS and thus inhibiting its autophagic degradation.