Recombinant Rabbit monoclonal primary
Recombinant USP11 Monoclonal Antibody (ET1705-38)
293T, A549, HepG2, SH-SY5Y, Hela.
Store at +4C after thawing. Aliquot store at -20C or -80C. Avoid repeated freeze / thaw cycles.
1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Protein A purified.
Deubiquitinating enzyme 11 antibody; Ubiquitin carboxyl-terminal hydrolase 11 antibody; Ubiquitin carboxyl-terminal hydrolase X linked antibody; ubiquitin specific peptidase 11 antibody; Ubiquitin specific protease 11 antibody; Ubiquitin thiolesterase 11 antibody; Ubiquitin-specific-processing protease 11 antibody; UBP11_HUMAN antibody; UHX1 antibody; USP11 antibody
Belongs to the peptidase C19 family.
Nucleus. Cytoplasm. Predominantly nuclear.
The ubiquitin (Ub) pathway involves three sequential enzymatic steps that facilitate the conjugation of Ub and Ub-like molecules to specific protein substrates. Through the use of a wide range of enzymes that can add or remove ubiquitin, the Ub pathway controls many intracellular processes such as signal transduction, transcriptional activation and cell cycle progression. USP11 (ubiquitin specific peptidase 11), also known as UHX1, is a 920 amino acid deubiquitinating enzyme that participates in the Ub pathway. Localized to the nucleus, USP11 associates with both Ran BP-M (Ran binding protein M) and with the tumor suppressor BRCA2. Through these associations, USP11 functions to either inhibit ubiquitination of these proteins or to remove ubiquitin residues that have already been attached to these proteins. USP11 is implicated in several X-linked retinal diseases and, due to its ability to deubiquitinate BRCA2, may play a role in tumor suppression.