Recombinant Rabbit monoclonal primary
Recombinant Tyrosinase Monoclonal Antibody (ET1704-18)
A431, B16F1, MCF-7, human liver tissue, human stomach carcinoma tissue.
Store at +4C after thawing. Aliquot store at -20C or -80C. Avoid repeated freeze / thaw cycles.
1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Protein A affinity purified.
ATN antibody; CMM8 antibody; LB24 AB antibody; LB24-AB antibody; Monophenol monooxygenase antibody; OCA1 antibody; OCA1A antibody; OCAIA antibody; Oculocutaneous albinism IA antibody; SHEP3 antibody; SK29 AB antibody; SK29-AB antibody; Tumor rejection antigen AB antibody; TYR antibody; TYRO_HUMAN antibody; tyrosinase (oculocutaneous albinism IA) antibody; Tyrosinase antibody
Belongs to the tyrosinase family.
Melanosome membrane, Melanosome.
This is a copper-containing oxidase that functions in the formation of pigments such as melanins and other polyphenolic compounds. Catalyzes the initial and rate limiting step in the cascade of reactions leading to melanin production from tyrosine. In addition to hydroxylating tyrosine to DOPA (3,4-dihydroxyphenylalanine), also catalyzes the oxidation of DOPA to DOPA-quinone, and possibly the oxidation of DHI (5,6-dihydroxyindole) to indole-5,6 quinone. Defects in TYR are the cause of albinism oculocutaneous type 1B (OCA1B) [MIM:606952]; also known as albinism yellow mutant type. An autosomal recessive disorder in which the biosynthesis of melanin pigment is reduced in skin, hair, and eyes. It is characterized by partial lack of tyrosinase activity.