Lane 1: PC-12 cell lysate
Lane 2: human skeletal muscle tissue lysate
Lane 3: NIH/3T3 cell lysate
Lane 4: Hela cell lysate
Recombinant Rabbit monoclonal primary
Recombinant TXNIP Monoclonal Antibody (ET1705-72)
PC-12 cell lysate, human skeletal muscle tissue lysate, NIH-3T3, Hela, SH-SY5Y, human kidney tissue, human stomach cancer tissue, mouse kidney tissue, mouse stomach tissue.
Store at +4C after thawing. Aliquot store at -20C or -80C. Avoid repeated freeze / thaw cycles.
1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Protein A purified.
Belongs to the arrestin family.
Ubiquitinated; undergoes polyubiquitination catalyzed by ITCH resulting in proteasomal degradation.
May act as an oxidative stress mediator by inhibiting thioredoxin activity or by limiting its bioavailability. Interacts with COPS5 and restores COPS5-induced suppression of CDKN1B stability, blocking the COPS5-mediated translocation of CDKN1B from the nucleus to the cytoplasm. Functions as a transcriptional repressor, possibly by acting as a bridge molecule between transcription factors and corepressor complexes, and over-expression will induce G0/G1 cell cycle arrest. Required for the maturation of natural killer cells. Acts as a suppressor of tumor cell growth. Inhibits the proteasomal degradation of DDIT4, and thereby contributes to the inhibition of the mammalian target of rapamycin complex 1 (mTORC1).