Lane 1: 293T
Lane 2: Hela
Recombinant Rabbit monoclonal primary
Recombinant TRK fused gene Monoclonal Antibody (ET1612-52)
293T cell lysate, Hela cell lysate, Hela, SKOV-3, A549, human tonsil tissue, mouse colon tissue, mouse kidney tissue, human lung carcinoma tissue, human kidney tissue.
Store at +4C after thawing. Aliquot store at -20C or -80C. Avoid repeated freeze / thaw cycles.
1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Protein A affinity purified.
TRK fused gene
FLJ36137 antibody; HMSNP antibody; OTTHUMP00000214045 antibody; OTTHUMP00000214046 antibody; OTTHUMP00000214047 antibody; OTTHUMP00000214048 antibody; Protein TFG antibody; SPG57 antibody; TF6 antibody; TFG antibody; TFG_HUMAN antibody; TRK fused antibody; TRK fused gene antibody; TRK fused gene protein antibody; TRK-fused gene protein antibody; TRKT3 antibody; TRKT3 oncogene antibody
Oncogenic rearrangements of the NTRK1 gene, which encodes the Trk A protein, are frequently detected in thyroid carcinomas. Such rearrangements fuse the NTRK1 tyrosine kinase domain to 5'-end sequences of different genes. TRK-T3 contains 1,412 nucleotides of NTRK1 preceded by 598 nucleotides belonging to TFG (TRK-fused gene), a ubiquitously expressed gene located on chromosome 3. The TRK-T3 protein within the TFG region contains a coiled-coil motif that gives the oncoprotein the capability to form complexes. The cytoplasmic TRK-T3 protein binds to and phosphorylates the Shc and SNT1/FRS2 adaptor proteins, both of which are involved in coupling the receptor tyrosine kinase to the mitogen-activated protein kinase pathway by recruiting Grb2/SOS. SHP-1 also interacts with and down-regulates TRK-T3.