Lane 1: mouse testis tissue lysate
Lane 2: MCF-7 cell lysate
Recombinant Rabbit monoclonal primary
Recombinant Topoisomerase II alpha Monoclonal Antibody (ET1607-59)
Synthetic peptide within human topoisomerase ii alpha aa 1500-1550
Human tonsil tissue, human kidney tissue, mouse testis tissue, mouse colon tissue, mouse kidney tissue.
Store at +4C after thawing. Aliquot store at -20C or -80C. Avoid repeated freeze / thaw cycles.
1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Protein A purified.
DNA topoisomerase 2-alpha
Belongs to the type II topoisomerase family.
Phosphorylation has no effect on catalytic activity. However, phosphorylation at Ser-1106 by CSNK1D/CK1 promotes DNA cleavable complex formation.
Cytoplasm. Nucleus, nucleoplasm. Note=Generally located in the nucleoplasm.
Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double-strand breaks. Essential during mitosis and meiosis for proper segregation of daughter chromosomes. May play a role in regulating the period length of ARNTL/BMAL1 transcriptional oscillation (By similarity).