Line 1: MCF-7
Line 2: Jurkat
Recombinant Rabbit monoclonal primary
Recombinant TNF Receptor II Monoclonal Antibody (ET1703-63)
Jurkat, MCF-7, HepG2, SW480, Hela, HL-60, human uterus tissue, human kidney tissue, mouse kidney tissue.
Store at +4C after thawing. Aliquot store at -20C or -80C. Avoid repeated freeze / thaw cycles.
1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Protein A purified.
Tumor necrosis factor receptor superfamily member 1B
TNF-R2, TNF-RII, TNFR-II, TNFRSF1B
Phosphorylated; mainly on serine residues and with a very low level on threonine residues.; A soluble form (tumor necrosis factor binding protein 2) is produced from the membrane form by proteolytic processing.
[Isoform 1]: Cell membrane; Single-pass type I membrane protein.; [Isoform 2]: Secreted.; [Tumor necrosis factor-binding protein 2]: Secreted.
Receptor with high affinity for TNFSF2/TNF-alpha and approximately 5-fold lower affinity for homotrimeric TNFSF1/lymphotoxin-alpha. The TRAF1/TRAF2 complex recruits the apoptotic suppressors BIRC2 and BIRC3 to TNFRSF1B/TNFR2. This receptor mediates most of the metabolic effects of TNF-alpha. Isoform 2 blocks TNF-alpha-induced apoptosis, which suggests that it regulates TNF-alpha function by antagonizing its biological activity.