UNIPROT #

P16035

PROTEIN NAME

TIMP2

SYNONYMS

CSC 21K antibody; CSC-21K antibody; CSC21K antibody; Metalloproteinase inhibitor 2 antibody; Metalloproteinase inhibitor 2 precursor antibody; TIMP 2 antibody; TIMP metallopeptidase inhibitor 2 antibody; TIMP-2 antibody; TIMP2 antibody; TIMP2_HUMAN antibody; Tissue Inhibitor of Metalloproteinase 2 antibody; Tissue inhibitor of metalloproteinases 2 antibody

SEQUENCE SIMILARITIES

Belongs to the protease inhibitor I35 (TIMP) family.

POST-TRANSLATIONAL MODIFICATION

The activity of TIMP2 is dependent on the presence of disulfide bonds.

SUBCELLULAR LOCATION

Secreted.

FUNCTION

TIMP-1, TIMP-2, TIMP-3 and TIMP-4 (for tissue inhibitor of metalloproteinases 1, 2, 3 and 4) complex with metalloproteinases such as collagenases, gelatin-ases and stromelysins, resulting in irreversible inactivation of the metallopro-teinase. TIMP-1 has been found to be identical to EPA (erythroid-potentiation activity). Parathyroid hormone has been shown to be a regulator of TIMP-2 in osteoblastic cells. TIMP-3 may be involved in regulating trophoblastic invasion of the uterus and remodeling of the extracellular matrix during the folding of epithelia, and in the formation, branching and expansion of epithelial tubes. TIMP-4 is most highly expressed in heart, with low levels expressed in liver, brain, lung, thymus and spleen.