Lane 1: Hela
Lane 2: Jurkat
Lane 3: Raji
Lane 4: Mouse testes
Lane 5: Mouse brain
Lane 6: Mouse spleen
Recombinant Rabbit monoclonal primary
Recombinant Thymidylate Synthase Monoclonal Antibody (ET1705-24)
Hela, Jurkat, Raji, mouse thymus, rat bone tissue, human tonsil tissue, mouse colon tissue.
Store at +4C after thawing. Aliquot store at -20C or -80C. Avoid repeated freeze / thaw cycles.
1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Protein A purified.
d TMP synthase antibody; EC 184.108.40.206 antibody; HsT422 antibody; MGC88736 antibody; OTTHUMP00000162195 antibody; Thymidylate synthase antibody; Thymidylate synthetase antibody; TMS antibody; TS antibody; TSase antibody; Tyms antibody; TYMS protein antibody; Tyms thymidylate synthetase antibody; TYSY_HUMAN antibody
Belongs to the thymidylate synthase family.
Nucleus. Cytoplasm. Mitochondrion.
Thymidylate synthase (TS), also designated TYMS, TMS, TSase and HsT422, uses 5,10-methylenetetrahydrofolate (methylene-THF) as a cofactor in the synthesis of 2'-deoxythymidine-5'-monophosphate (dTMP), an essential precursor for DNA biosynthesis. TS is an RNA-binding protein that can interact with its own mRNA. The TS/mRNA ribonucleoprotein complex can also associate with a number of other cellular mRNAs, including those corresponding to the p53 tumor suppressor gene and the Myc family of transcription factors. Inhibition of DNA replication and cell death resulting from thymidine depletion occurs when TS enzyme activity is inhibited with substrate or cofactor analogs, making the TS enzyme an important target for chemotherapy. Cancer cells are sensitive to thymidine depletion, as they multiply rapidly.