Lane 1: K562
Lane 2: Hela
Recombinant Rabbit monoclonal primary
Recombinant STAT5b Monoclonal Antibody (ET1612-63)
PC-3M, RH-35, Hela, K562, human spleen tissue, human breast carcinoma tissue, mouse testis tissue, mouse colon tissue.
Store at +4C after thawing. Aliquot store at -20C or -80C. Avoid repeated freeze / thaw cycles.
1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Protein A purified.
Signal transducer and activator of transcription 5B
Belongs to the transcription factor STAT family.
Tyrosine phosphorylated in response to signaling via activated KIT, resulting in translocation to the nucleus. Tyrosine phosphorylated in response to signaling via activated FLT3; wild-type FLT3 results in much weaker phosphorylation than constitutively activated mutant FLT3. Alternatively, can be phosphorylated by JAK2. Phosphorylation at Tyr-699 by PTK6 or HCK leads to an increase of its transcriptional activity.
Cytoplasm. Nucleus. Note=Translocated into the nucleus in response to phosphorylation.
Carries out a dual signal transduction and activation of transcription. Mediates cellular responses to the cytokine KITLG/SCF and other growth factors. Binds to the GAS element and activates PRL-induced transcription. Positively regulates hematopoietic/erythroid differentiation.