Recombinant Rabbit monoclonal primary
Recombinant SOX9 Monoclonal Antibody (ET1611-56)
SW480 cell lysates, MCF-7, SW480, human tonsil tissue, human breast carcinoma tissue, mouse colon tissue, mouse spleen tissue, Hela.
Store at +4C after thawing. Aliquot store at -20C or -80C. Avoid repeated freeze / thaw cycles.
1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Protein A affinity purified.
campomelic dysplasia autosomal sex reversal antibody; CMD 1 antibody; CMD1 antibody; CMPD 1 antibody; CMPD1 antibody; SOX 9 antibody; Sox9 antibody; SOX9_HUMAN antibody; SRA 1 antibody; SRA1 antibody; SRXX2 antibody; SRXY10 antibody; SRY (sex determining region Y) box 9 (campomelic dysplasia autosomal antibody; SRY (sex determining region Y) box 9 antibody; SRY (sex determining region Y)-box 9 antibody; SRY (sex-determining region Y)-box 9 protein antibody; SRY related HMG box gene 9 antibody; Transcription factor SOX 9 antibody; Transcription factor SOX-9 antibody; transcription factor SOX9 antibody
Acetylated; acetylation impairs nuclear localization and ability to transactivate expression of target genes. Deacetylated by SIRT1.; Phosphorylation at Ser-64 and Ser-211 by PKA increases transcriptional activity and may help delay chondrocyte maturation downstream of PTHLH/PTHrP signaling. Phosphorylation at either Ser-64 or Ser-211 is required for sumoylation, but phosphorylation is not dependent on sumoylation. Phosphorylated on tyrosine residues; tyrosine dephosphorylation by PTPN11/SHP2 blocks SOX9 phosphorylation by PKA and subsequent SUMOylation.; Ubiquitinated; ubiquitination leads to proteasomal degradation and is negatively regulated by DDRGK1.; Sumoylated; phosphorylation at either Ser-64 or Ser-211 is required for sumoylation. Sumoylation is induced by BMP signaling pathway.
Sox genes comprise a family of genes that are related to the mammalian sex determining gene SRY. These genes similarly contain sequences that encode for the HMG-box domain, which is responsible for the sequence-specific DNA-binding activity. Sox genes encode putative transcriptional regulators implicated in the decision of cell fates during development and the control of diverse developmental processes. The highly complex group of Sox genes cluster at least 40 different loci that rapidly diverged in various animal lineages. At present, 30 Sox genes have been identified. Members of this family have been shown to be conserved during evolution and to play key roles during animal development. Some are involved in human diseases, including sex reversal.
Huang, Bao et al.
The RCAN1.4-calcineurin/NFAT signaling pathway is essential for hypoxic adaption of intervertebral discs. | Experimental & Molecular Medicine