PRODUCT CODE: ET1609-11

Recombinant SOX18 Monoclonal Antibody (ET1609-11)

  • Recombinant

Applications

  • WB

  • IHC-P

REACTIVITY

  • Human

  • Mouse

  • Rat

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Western blot analysis of SOX18 on K562 cells lysates using anti-SOX18 antibody at 1/1,000 dilution.
  • Western blot analysis of SOX18 on K562 cells lysates using anti-SOX18 antibody at 1/1,000 dilution.
Western blot analysis of SOX18 on K562 cells lysates using anti-SOX18 antibody at 1/1,000 dilution.

Applications

  • WB

  • IHC-P

REACTIVITY

  • Human

  • Mouse

  • Rat

SPECIFICATIONS

Product Type

Recombinant Rabbit monoclonal primary

Product Name

Recombinant SOX18 Monoclonal Antibody (ET1609-11)

Immunogen

Recombinant protein

Host

Rabbit

Positive Control

K562.

Conjugation

Unconjugated

Clonality

Monoclonal

Clone Number

ST43-02

PROPERTIES

Form

Liquid

Storage Condition

Store at +4C after thawing. Aliquot store at -20C or -80C. Avoid repeated freeze / thaw cycles.

Storage Buffer

1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.

Concentration

1 ug/ul

PURIFICATION

Protein A purified.

MOLECULAR WEIGHT

41 kDa

Isotype

IgG

APPLICATION DILUTION

  • WB

  • 1:1,000

  • IHC-P:1:50-1:200

TARGET

UNIPROT #

PROTEIN NAME

SOX18

SYNONYMS

HLTS antibody; SOX 18 antibody; Sox18 antibody; SOX18_HUMAN antibody; SRY (sex determining region Y) box 18 antibody; SRY box 18 antibody; Transcription factor SOX 18 antibody; Transcription factor SOX-18 antibody

TISSUE SPECIFICITY

Detected in heart, lung, placenta, skeletal muscle, liver, kidney, spleen, prostate, ovary, msosmall intestine and colon.

SUBCELLULAR LOCATION

Nucleus.

FUNCTION

Sox genes comprise a family of genes that are related to the mammalian sex determining gene SRY. These genes similarly contain sequences that encode for the HMG-box domain, which is responsible for the sequence-specific DNA-binding activity. Sox genes encode putative transcriptional regulators implicated in the decision of cell fates during development and the control of diverse developmental processes. The highly complex group of Sox genes cluster at least 40 different loci that rapidly diverged in various animal lineages. At present, 30 Sox genes have been identified. Members of this family have been shown to be conserved during evolution and to play key roles during animal development. Some are involved in human diseases, including sex reversal. Sox-18 is a 384 amino acid nuclear protein that contains one HMG box DNA-binding domain and belongs to the Sox family of transcriptional regulators.