Recombinant Rabbit monoclonal primary
Recombinant Rhodopsin Monoclonal Antibody (ET1704-12)
Rat retina tissue.
Store at +4C after thawing. Aliquot store at -20C or -80C. Avoid repeated freeze / thaw cycles.
1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Protein A purified.
CSNBAD1 antibody; MGC138309 antibody; MGC138311 antibody; OPN 2 antibody; OPN2 antibody; opsd antibody; OPSD_HUMAN antibody; opsin 2 antibody; Opsin 2 rod pigment antibody; Opsin-2 antibody; Opsin2 antibody; Retinitis Pigmentosa 4 antibody; Retinitis pigmentosa 4 autosomal dominant antibody; RHO antibody; Rhodopsin antibody; RP 4 antibody; RP4 antibody
Belongs to the G-protein coupled receptor 1 family. Opsin subfamily.
Rod shaped photoreceptor cells which mediate vision in dim light.
Phosphorylated on some or all of the serine and threonine residues present in the C-terminal region (By similarity). After activation by light, phosphorylated by GRK1 (in vitro).; Contains one covalently linked retinal chromophore. Upon light absorption, the covalently bound 11-cis-retinal is converted to all-trans-retinal. After hydrolysis of the Schiff base and release of the covalently bound all-trans-retinal, active rhodopsin is regenerated by binding of a fresh molecule of 11-cis-retinal(PubMed:12566452).
In aerobic respiration reactions, succinate dehydrogenase (SDH) catalyzes the oxidation of succinate and ubiquinone to fumarate and ubiquinol. Four subunits comprise the SDH protein complex: a flavochrome subunit (SDHA), an iron-sulfur protein (SDHB), and two membrane-bound subunits (SDHC and SDHD) anchored to the inner mitochondrial membrane. Mutations to these subunits cause mitochondrial dysfunction, corresponding to several distinct disorders. Mutations in the membrane bound components may cause hereditary paraganglioma, while SDHA mutations are associated with juvenile encephalopathy as well as Leigh Syndrome, a severe neurological disorder. Inactivating mutations in SDHB correlate with inherited, but not necessarily sporadic, cases of pheochromocytoma.