Lane 1: HepG2
Lane 2: Hela
Lane 3: Jurkat
Recombinant Rabbit monoclonal primary
Recombinant Rho A+B+C Monoclonal Antibody (ET1602-23)
Jurkat, NIH/3T3, Hela, HepG2, mouse stomach tissue, human gastric carcinoma tissue, mouse colon tissue.
Store at +4C after thawing. Aliquot store at -20C or -80C. Avoid repeated freeze / thaw cycles.
1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Protein A purified.
AA017882 antibody; AI324259, antibody; Aplysia ras related homolog 9 (RhoC) antibody; Aplysia ras-related homolog 12 antibody; Aplysia RAS-related homolog 6 antibody; Aplysia RAS-related homolog antibody; ARH12 antibody; ARH6 antibody; ARH9 antibody; ARHA antibody; ARHB antibody; ARHC antibody; H12 antibody; H6 antibody; H9 antibody; MGC117867 antibody; MGC1448 antibody; MGC61427 antibody; MST081 antibody; MSTP081 antibody; Oncogene RHO H12 antibody; Oncogene RHO H6 antibody; Oncogene RHO H9 antibody; OTTHUMP00000013675 antibody; OTTHUMP00000013676 antibody; OTTHUMP00000013802 antibody; OTTHUMP00000013805 antibody; OTTHUMP00000013807 antibody; OTTHUMP00000013809 antibody; OTTMUSP00000025086 antibody; OTTMUSP00000025087 antibody; Ras homolog 9 (RhoC) antibody; Ras homolog gene family, member A antibody; Ras homolog gene family, member B antibody; Ras homolog gene family, member C antibody; RAS-related homolog 9 antibody; Rh -related GTP binding protein RhoC antibody; Rho cDNA clone 12 antibody; rho cDNA clone 6 antibody; rho cDNA clone 9 antibody; Rho related GTP binding protein RhoB antibody; Rho related GTP binding protein RhoC antibody; RHO12 antibody; RHOA antibody; RHOB antibody; RHOC antibody; rhoC GTPase antibody; RHOH12 antibody; RHOH6 antibody; RHOH9 antibody; RP11-426L16.4 antibody; small GTP binding protein RhoA antibody; Small GTP binding protein RhoC antibody; Transforming protein RhoA antibody
Belongs to the small GTPase superfamily. Rho family.
(Microbial infection) Glycosylated at Tyr-34 by Photorhabdus asymbiotica toxin PAU_02230. Mono-O-GlcNAcylation by PAU_02230 inhibits downstream signaling by an impaired interaction with diverse regulator and effector proteins of Rho and leads to actin disassembly.
Cytoplasm, Nucleus, Cell membrane, Cleavage furrow.
The Ras p21 family of guanine nucleotide proteins has been widely studied in view of its apparent role in signal transduction pathways and high frequency of mutations in human malignancies. It is now clear, however, that the Ras proteins (H-, K- and N-Ras p21) are members of a much larger superfamily of related proteins. Six members of this family, Rap 1A, Rap 1B, Rap 2, R-Ras, Ral A and Ral B, exhibit approximately 50% amino acid homology to Ras. The six mammalian Rho proteins (Rho A, B, C, G, 7 and 8) are approximately 30% homologous to Ras and are expressed in a wide range of cell types. Both Ras p21 and Rho p21, as well as other members of the Ras superfamily, contain a carboxy-terminal CAAX sequence (C, cysteine; A, aliphatic amino acid; X, any amino acid) which in the case of Ras has been shown to be essential for correct localization and function.