Lane 1: mouse brain tissue lysate
Lane 2: human brain tissue lysate
Lane 3: rat brain tissue lysate
Recombinant Rabbit monoclonal primary
Recombinant PSD95 Monoclonal Antibody (ET1602-20)
Synthetic peptide within human psd95 aa 1-40.
Mouse brain tissue lysate, human brain tissue lysate, rat brain tissue lysate, N2A, SH-SY5Y, rat brain tissue, mouse cerebullum tissue.
Store at +4C after thawing. Aliquot store at -20C or -80C. Avoid repeated freeze / thaw cycles.
1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Protein A affinity purified.
Discs large homolog 4 antibody; Disks large homolog 4 antibody; DLG 4 antibody; Dlg4 antibody; DLG4_HUMAN antibody; FLJ97752 antibody; FLJ98574 antibody; Human post synaptic density protein 95 antibody; Post synaptic density protein 95 antibody; Postsynaptic density protein 95 antibody; PSD 95 antibody; PSD-95 antibody; PSD95 antibody; SAP 90 antibody; SAP-90 antibody; SAP90 antibody; Synapse associated protein 90 antibody; Synapse-associated protein 90 antibody; Tax interaction protein 15 antibody
Belongs to the MAGUK family.
Palmitoylated. Palmitoylation is required for targeting to postsynaptic density, plasma membrane and synapses (By similarity). Palmitoylation by ZDHHC2 occurs when the synaptic activity decreases and induces DLG4 synaptic clustering (By similarity). Palmitoylation may play a role in glutamate receptor GRIA1 synapse clustering (By similarity). Depalmitoylated by ABHD17A and ABHD17B and to a lesser extent by ABHD17C, ABHD12, ABHD13, LYPLA1 and LYPLA2. Undergoes rapid synaptic palmitoylation/depalmitoylation cycles during neuronal development which slow down in mature neurons (By similarity).; Ubiquitinated by MDM2 in response to NMDA receptor activation, leading to proteasome-mediated degradation of DLG4 which is required for AMPA receptor endocytosis.
Cell membrane, Cell junction
The Drosophila discs large (dlg) tumor suppressor gene was first identified in Drosophila through genetic analysis of germline mutations. Several mammalian homologs were subsequently identified and categorized into a protein family termed MAGUK (membrane-associated guanylate kinase homolog). Human homologs of dlg include hdlg-1 (rat SAP 97) and NE-dlg (neuronal and endocrine dlg). The rat synaptic protein PSD-95 (also designated SAP 90) also shares homology with these proteins. MAGUKs are localized at the membrane-cytoskeleton interface and contain several distinct domains which suggest a role for these proteins in intracellular signal transduction. Interaction of hdlg-1 and NE-dlg with the tumor suppresor protein APC suggest that MAGUK proteins may also play a role in regulation of growth.