Recombinant Rabbit monoclonal primary
Recombinant PRP19 Monoclonal Antibody (ET1610-54)
Jurkat, MCF-7, Hela, B16-F1, mouse brain tissue, human lung cancer tissue, mouse kidney tissue, human breast carcinoma tissue, human kidney tissue.
Store at +4C after thawing. Aliquot store at -20C or -80C. Avoid repeated freeze / thaw cycles.
1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Protein A purified.
hPso4 antibody; NMP200 antibody; Nuclear matrix protein 200 antibody; Nuclear matrix protein NMP200 related to splicing factor PRP19 antibody; pre mRNA processing factor 19 antibody; Pre-mRNA-processing factor 19 antibody; PRP19 antibody; PRP19/PSO4 homolog antibody; PRP19/PSO4 pre-mRNA processing factor 19 homolog (S. cerevisiae) antibody; PRP19_HUMAN antibody; PRPF19 antibody; PSO4 antibody; psoralen 4 antibody; Senescence evasion factor antibody; SNEV antibody; UBOX4 antibody
Belongs to the WD repeat PRP19 family.
Ubiquitous. Weakly expressed in senescent cells of different tissue origins. Highly expressed in tumor cell lines.
Nucleus, Cytoplasm, Lipid droplet.
The spliceosome, the 0gigantic molecular machine that performs pre-mRNA splicing in eukaryotes, contains over 200 different proteins and five RNA molecules (U1, U2, U4, U5 and U6). Pre-mRNA splicing is essential to remove internal non-coding regions of pre-mRNA (introns) and to join the remaining segments (exons) into mRNA before translation. The PRP19-associated complex is required for stable association of U5 and U6 with the spliceosome after U4 is released. Changes within the spliceosome upon binding of the PRP19-associated complex include remodeling of the U6/5' splice site interaction and destabilization of Lsm proteins to allow further interaction of U6 with the intron sequence.