Lane 1: K562
Lane 2: 293
Recombinant Rabbit monoclonal primary
Recombinant PKC alpha Monoclonal Antibody (ET1608-15)
K562, MCF-7, Hela, CRC, A549, PC12, mouse brain tissue, mouse small intestine tissue, mouse heart tissue, human lung tissue.
Store at +4C after thawing. Aliquot store at -20C or -80C. Avoid repeated freeze / thaw cycles.
1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Protein A purified.
AAG6 antibody; Aging associated gene 6 antibody; aPKC antibody; KPCA_HUMAN antibody; PKC alpha antibody; PKC-A antibody; PKC-alpha antibody; PKCA antibody; PRKACA antibody; PRKCA antibody; Protein Kinase C alpha antibody; Protein kinase C alpha type antibody
Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.
Cytoplasm, Nucleus, Cell membrane, Mitochondrion membrane.
Members of the protein kinase C (PKC) family play a key regulatory role in a variety of cellular functions including cell growth and differentiation, gene expression, hormone secretion and membrane function. PKCs were originally identified as serine/threonine protein kinases whose activity was dependent on calcium and phospholipids. Diacylglycerols (DAG) and tumor-promoting phorbol esters bind to and activate PKC. PKCs can be subdivided into many different isoforms. Patterns of expression for each PKC isoform differ among tissues and PKC family members exhibit clear differences in their cofactor dependencies. For instance, the kinase activities of PKC and é are independent of Ca2+. On the other hand, most of the other PKC members possess phorbol ester-binding activities and kinase activities.
Liu, Suzi et al.
Sinomenine protects against E.coli-induced acute lung injury in mice through Nrf2-NF-�B pathway. | Biomedicine & Pharmacotherapy = Biomedecine & Pharmacotherapie