Lane 1: BT-20 cell lysate
Lane 2: HepG2 cell lysate
Lane 3: SW480 cell lysate
Recombinant Rabbit monoclonal primary
Recombinant PIM1 Monoclonal Antibody (ET1609-57)
BT-20 cell lysate, HepG2 cell lysate, SW480 cell lysate, BT-20, HepG2, SW480, human tonsil tissue, human colon carcinoma tissue, human spleen tissue, human breast carcinoma tissue.
Store at +4C after thawing. Aliquot store at -20C or -80C. Avoid repeated freeze / thaw cycles.
1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Protein A affinity purified.
Oncogene PIM 1 antibody; Oncogene PIM1 antibody; PIM 1 antibody; pim 1 kinase 44 kDa isoform antibody; Pim 1 kinase antibody; pim 1 oncogene (proviral integration site 1) antibody; Pim 1 oncogene antibody; PIM antibody; PIM1 antibody; pim1 kinase 44 kDa isoform antibody; PIM1_HUMAN antibody; Pim2 antibody; PIM3 antibody; Proto oncogene serine/threonine protein kinase Pim 1 antibody; Proto-oncogene serine/threonine-protein kinase Pim-1 antibody; Proviral integration site 1 antibody; Proviral integration site 2 antibody
Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. PIM subfamily.
Expressed primarily in cells of the hematopoietic and germline lineages. Isoform 1 and isoform 2 are both expressed in prostate cancer cell lines.
Autophosphorylated on both serine/threonine and tyrosine residues. Phosphorylated. Interaction with PPP2CA promotes dephosphorylation.; Ubiquitinated, leading to proteasomal degradation.
Cytoplasm, Nucleus, Cell membrane.
Pim-1 is a serine/threonine kinase that cooperates with c-Myc in lymphoid cell transformation. The expression of pim-1 increases during the progression from early to late G1, remaining high at the G1/S boundary and G2 phases of the cell cycle. Pim-1 is regulated at both the transcriptional and translational level, and it has been shown to be induced by IL-2 stimulation. Pim-1 also plays a role in T cell differentiation, and it has been shown to stimulate c-Myc-mediated apoptosis upstream of caspase-3-like proteases.