Recombinant Rabbit monoclonal primary
Recombinant PI 3 Kinase Class 3 Monoclonal Antibody (ET1607-74)
C2C12 cell lysates, rat brain tissue, human stomach carcinoma tissue, mouse brain tissue, A549.
Store at +4C after thawing. Aliquot store at -20C or -80C. Avoid repeated freeze / thaw cycles.
1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Protein A affinity purified.
PI 3 Kinase Class 3
hVps34 antibody; MGC61518 antibody; Phosphatidylinositol 3 kinase catalytic subunit type 3 antibody; Phosphatidylinositol 3 kinase class 3 antibody; Phosphatidylinositol 3 kinase p100 subunit antibody; Phosphatidylinositol 3-kinase catalytic subunit type 3 antibody; Phosphatidylinositol 3-kinase p100 subunit antibody; Phosphoinositide 3 kinase class 3 antibody; Phosphoinositide-3-kinase class 3 antibody; PI3 kinase type 3 antibody; PI3-kinase type 3 antibody; PI3K type 3 antibody; Pik3c3 antibody; PK3C3_HUMAN antibody; PtdIns 3 kinase type 3 antibody; PtdIns-3-kinase type 3 antibody; Vps 34 antibody; Vps34 antibody
Belongs to the PI3/PI4-kinase family.
Ubiquitously expressed, with a highest expression in skeletal muscle.
Midbody, Late endosome, Cytoplasmic vesicle.
Phosphatidylinositol 3-kinases (PI3Ks) phosphorylate the 3' OH position of the inositol ring of inositol lipids. PI 3-kinase p100 (phosphoinositide-3-kinase p100 subunit), also known as hVps34 or PIK3C3 (phosphoinositide-3-kinase, class III), is a member of the PI3/PI4-kinase family. It is ubiquitously expressed with predominant expression in skeletal muscle and is believed to participate in endosome to lysosome transport, multivesicular body formation, autophagy and retrograde endosome to Golgi transport. PI 3-kinase p100 is the catalytic subunit of class III PI3Ks and forms a heterodimer with p150, a regulatory subunit of class 3 PI3Ks. PI 3-kinase p100 exclusively phosphorylates phosphatidylinositol to produce PtdIns3P. Unlike class I PI3Ks, whose activities are enhanced in the presence of magnesium, PI 3-kinase p100 activity is enhanced by manganese. Its activity can also be regulated by nutrients, suggesting an important role of PI-3 kinase p100 in the regulation of mTOR protein synthesis and autophagy.