Recombinant Rabbit monoclonal primary
Recombinant Phospho P-V-Myb+C-Myb (S11) Monoclonal Antibody (ET1603-41)
Synthetic phospho-peptide corresponding to residues surrounding ser11 of human v-myb+c-myb.
Ags, human uterine neck tissue, human breast carcinoma tissue.
Store at +4C after thawing. Aliquot store at -20C or -80C. Avoid repeated freeze / thaw cycles.
1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Protein A purified.
C myb antibody; C myb protein antibody; Cmyb antibody; MYB antibody; Myb proto oncogene antibody; V myb myeloblastosis viral oncogene homolog antibody
Ubiquitinated; mediated by SIAH1 and leading to its subsequent proteasomal degradation.; Phosphorylated by NLK on multiple sites, which induces proteasomal degradation.; Phosphorylated by HIPK1. This phosphorylation reduces MYB transcription factor activity but not MYB protein levels.
The Myb family of transcription factors regulates proliferation, differentiation and apoptosis of hematopoletic cells. The avian myeloblastosis viral (v-Myb) protein is nuclear and binds to specific DNA sequences. The gene encoding for v-Myb is oncogenic, causing monoblastic leukemia and transforming myelomonocytic cells by deregulating the expression of specific target genes. v-Myb functions as a transcriptional activator, and it can repress biologically relevant genes such as Ets-2, which promotes macrophage differentiation. The proto-oncogene c-Myb encodes for a nuclear protein that plays a role in transcriptional regulation and may be essential for hematopoietic cell proliferation. A-Myb is also member of the Myb family that is expressed in proliferating B cell centroblasts. Transgenic mice overexpressing A-Myb posses enhanced hyperplasia of the lymph nodes.