Recombinant Rabbit monoclonal primary
Recombinant Phospho MLKL (Phospho S345) Monoclonal Antibody (ET1705-51)
Synthetic phospho-peptide corresponding to residues surrounding ser345 of human mlkl.
Mouse spleen tissue, mouse lung tissue, mouse liver tissue, mouse colon tissue.
Store at +4C after thawing. Aliquot store at -20C or -80C. Avoid repeated freeze / thaw cycles.
1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Protein A affinity purified.
MLKL (phospho S345)
9130019I15Rik antibody; FLJ34389 antibody; hMLKL antibody; Mixed lineage kinase domain like antibody; Mixed lineage kinase domain like protein antibody; Mixed lineage kinase domain like pseudokinase antibody; Mixed lineage kinase domain-like protein antibody; Mlkl antibody; MLKL_HUMAN antibody
Belongs to the protein kinase superfamily.
Highly expressed in thymus, colon, intestine, liver, spleen and lung. Expressed at much lower level in skeletal muscle, heart and kidney. Not detected in brain.
Phosphorylation by RIPK3 induces a conformational switch that is required for necroptosis. It also induces homotrimerization and localization to the plasma membrane.
Pseudokinase that plays a key role in TNF-induced necroptosis, a programmed cell death process. Activated following phosphorylation by RIPK3, leading to homotrimerization, localization to the plasma membrane and execution of programmed necrosis characterized by calcium influx and plasma membrane damage. Does not have protein kinase activity.