Lane 1: mouse spleen tissue lysate
Lane 2: rat spleen tissue lysate
Recombinant Rabbit monoclonal primary
Recombinant Phospho eIF4E (S209) Monoclonal Antibody (ET1608-66)
Synthetic phospho-peptide corresponding to residues surrounding ser209 of human eif4e.
N2A, SH-SY-5Y, 293, rat spleen tissue, human spleen tissue, mouse spleen tissue.
Store at +4C after thawing. Aliquot store at -20C or -80C. Avoid repeated freeze / thaw cycles.
1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Protein A purified.
Eukaryotic translation initiation factor 4E
eIF-4E, eIF4E, EIF4E
Belongs to the eukaryotic initiation factor 4E family.
Phosphorylation increases the ability of the protein to bind to mRNA caps and to form the eIF4F complex.
Cytoplasm, P-body. Cytoplasm. Cytoplasm, Stress granule.
Recognizes and binds the 7-methylguanosine-containing mRNA cap during an early step in the initiation of protein synthesis and facilitates ribosome binding by inducing the unwinding of the mRNAs secondary structures. Component of the CYFIP1-EIF4E-FMR1 complex which binds to the mRNA cap and mediates translational repression. In the CYFIP1-EIF4E-FMR1 complex this subunit mediates the binding to the mRNA cap.