Lane 1: HUVEC cell lysate
Lane 2: Hela cell lysate
Lane 2: PC-3M cell lysate
Recombinant Rabbit monoclonal primary
Recombinant Phospho eIF-2a (S51) Monoclonal Antibody (ET1603-14)
Synthetic phospho-peptide corresponding to residues surrounding ser51 of human eif-2a.
HUVEC cell lysate, Hela cell lysate, PC-3M cell lysate, Hela, human liver tissue, human pancreas tissue, mouse brain tissue, mouse placenta tissue, mouse pancreas tissue, human prostate carcinoma tissue.
Store at +4C after thawing. Aliquot store at -20C or -80C. Avoid repeated freeze / thaw cycles.
1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Protein A affinity purified.
EIF 2 alpha antibody; EIF 2 antibody; EIF 2A antibody; EIF 2alpha antibody; eIF-2-alpha antibody; eIF-2A antibody; EIF-2alpha antibody; EIF2 alpha antibody; EIF2 antibody; EIF2A antibody; EIF2S1 antibody; Eukaryotic translation initiation factor 2 subunit 1 alpha 35kDa antibody; Eukaryotic translation initiation factor 2 subunit 1 alpha antibody; Eukaryotic translation initiation factor 2 subunit 1 antibody; Eukaryotic translation initiation factor 2 subunit alpha antibody; IF2A_HUMAN antibody
Belongs to the WD repeat EIF2A family.
Widely expressed. Expressed at higher level in pancreas, heart, brain and placenta.
Phosphorylation of the eukaryotic initiation factor 2 (eIF2) α subunit is a well-documented mechanism to downregulate protein synthesis under a variety of stress conditions. Eukaryotic initiation factor 2 binds GTP and Met-tRNAi and transfers Met-tRNA to the 40S subunit to form the 43S preinitiation complex. eIF2 promotes a new round of translation initiation by exchanging GDP for GTP, a reaction catalyzed by eIF2B. Kinases that are activated by viral infection (PKR), endoplasmic reticulum stress (PERK/PEK), amino acid deprivation (GCN2), or heme deficiency (HRI) can phosphorylate the α subunit of eIF2. This phosphorylation stabilizes the eIF2-GDP-eIF2B complex and inhibits the turnover of eIF2B. Induction of PKR by IFN-γ and TNF-α induces potent phosphorylation of eIF2α at Ser51.
Liu, Yin et al.
Retinoic acid receptor-related orphan receptor � stimulates adipose tissue inflammation by modulating endoplasmic reticulum stress. | The Journal of Biological Chemistry 
Tan, Zhouke et al.
Pharmacological and genetic inhibition of fatty acid-binding protein 4 alleviated cisplatin-induced acute kidney injury. | Journal of Cellular and Molecular Medicine 
Hao, Yan et al.
2-Methylquinazoline derivative 23BB as a highly selective histone deacetylase 6 inhibitor alleviated cisplatin-induced acute kidney injury. | Bioscience Reports 
Huang, Zhuo et al.
Activation of GPR120 by TUG891 ameliorated cisplatin-induced acute kidney injury via repressing ER stress and apoptosis. | Biomedicine & Pharmacotherapy = Biomedecine & Pharmacotherapie