Recombinant Rabbit monoclonal primary
Recombinant Phospho Cyclin E1(T77) Monoclonal Antibody (ET1612-31)
Synthetic phospho-peptide corresponding to residues surrounding thr77 of human cyclin e1.
SW480, Hela, HepG2, human tonsil tissue, human colon cancer tissue.
Store at +4C after thawing. Aliquot store at -20C or -80C. Avoid repeated freeze / thaw cycles.
1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Protein A purified.
Belongs to the cyclin family. Cyclin E subfamily.
Highly expressed in testis and placenta. Low levels in bronchial epithelial cells.
Phosphorylation of both Thr-395 by GSK3 and Ser-399 by CDK2 creates a high affinity degron recognized by FBXW7, and accelerates degradation via the ubiquitin proteasome pathway. Phosphorylation at Thr-77 creates a low affinity degron also recognized by FBXW7.; Ubiquitinated by UHRF2; appears to occur independently of phosphorylation.
Essential for the control of the cell cycle at the G1/S (start) transition.