PRODUCT CODE: ET1705-65

Recombinant PGC1 beta Monoclonal Antibody (ET1705-65)

  • Recombinant

Applications

  • WB

  • IP

  • FC

REACTIVITY

  • Human

  • Rat

Western blot analysis of PGC1 beta on rat spleen tissue lysate using anti-PGC1 beta antibody at 1/1,000 dilution.
  • Western blot analysis of PGC1 beta on rat spleen tissue lysate using anti-PGC1 beta antibody at 1/1,000 dilution.
  • Flow cytometric analysis of HL-60 cells with PGC1 beta antibody at 1/100 dilution (red) compared with an unlabelled control (cells without incubation with primary antibody; black).
Western blot analysis of PGC1 beta on rat spleen tissue lysate using anti-PGC1 beta antibody at 1/1,000 dilution.

Applications

  • WB

  • IP

  • FC

REACTIVITY

  • Human

  • Rat

SPECIFICATIONS

Product Type

Recombinant Rabbit monoclonal primary

Product Name

Recombinant PGC1 beta Monoclonal Antibody (ET1705-65)

Immunogen

Recombinant protein

Host

Rabbit

Positive Control

Rat spleen tissue lysate, HL-60.

Conjugation

Unconjugated

Clonality

Monoclonal

Clone Number

JM33-24

PROPERTIES

Form

Liquid

Storage Condition

Store at +4C after thawing. Aliquot store at -20C or -80C. Avoid repeated freeze / thaw cycles.

Storage Buffer

1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.

Concentration

1 ug/ul

PURIFICATION

Protein A purified.

Isotype

IgG

APPLICATION DILUTION

  • WB

  • 1:500-1:2,000

  • FC

  • 1:50-1:200

  • IP

  • 1:10-1:50

TARGET

UNIPROT #

PROTEIN NAME

Peroxisome proliferator-activated receptor gamma coactivator 1-beta

GENE NAME

PPARGC1B

SYNONYMS

PGC-1-beta, PPAR-gamma coactivator 1-beta, PPARGC-1-beta, PPARGC1B, PERC, PGC1, PGC1B, PPARGC1

TISSUE SPECIFICITY

Ubiquitous with higher expression in heart, brain and skeletal muscle.

SUBCELLULAR LOCATION

Nucleus.

FUNCTION

Plays a role of stimulator of transcription factors and nuclear receptors activities. Activates transcriptional activity of estrogen receptor alpha, nuclear respiratory factor 1 (NRF1) and glucocorticoid receptor in the presence of glucocorticoids. May play a role in constitutive non-adrenergic-mediated mitochondrial biogenesis as suggested by increased basal oxygen consumption and mitochondrial number when overexpressed. May be involved in fat oxidation and non-oxidative glucose metabolism and in the regulation of energy expenditure. Induces the expression of PERM1 in the skeletal muscle in an ESRRA-dependent manner.