UNIPROT #

Q16875

PROTEIN NAME

PFKFB3

SYNONYMS

6 phosphofructo 2 kinase/ fructose 2,6 bisphosphatase antibody; 6 phosphofructo 2 kinase/fructose 2,6 biphosphatase 3 antibody; 6-bisphosphatase antibody; 6-P2ase 3 antibody; 6-P2ASE brain/placenta-type isozyme antibody; 6PF 2 K/Fru 2,6 P2ASE brain/placenta type isozyme antibody; 6PF 2-K/Fru 2,6 P2ase 3 antibody; 6PF-2-K/Fru-2 antibody; F263_HUMAN antibody; fructose 6 phosphate,2 kinase/fructose 2, 6 bisphosphatase antibody; Fructose-2 antibody; Inducible 6 phosphofructo 2 kinase/fructose 2,6 bisphosphatase antibody; iPFK 2 antibody; iPFK-2 antibody; IPFK2 antibody; PFK/FBPase 3 antibody; PFK2 antibody; PFKFB3 antibody; Renal carcinoma antigen NY REN 56 antibody; Renal carcinoma antigen NY-REN-56 antibody; uPFK 2 antibody

SEQUENCE SIMILARITIES

In the C-terminal section; belongs to the phosphoglycerate mutase family.

TISSUE SPECIFICITY

Ubiquitous.

POST-TRANSLATIONAL MODIFICATION

Phosphorylation by AMPK stimulates activity.

SUBCELLULAR LOCATION

Cytosol. Nucleoplasm.

FUNCTION

Among the enzymes playing role in glycolysis,four allosteric PFKFB enzymes 1–4 expressed by four independent PFKFB genes, catalyze the rate-limiting phosphorylation of fructose-6-phosphate to fructose-1, 6-bisphosphate, using ATP as the energy source in the glycolysis pathway. Among these four allosteric enzymes, PFKFB3 enzyme retains the highest Kinase/Biphosphatase activity ratio and is expressed by PFKFB3 gene which has been demonstrated to be highly expressed in leukemic cells and in solid tumors. Moreover, mitogenic, hypoxic and inflammatory conditions have an inductive effect on the expression of PFKFB3. Hence upregulation of PFKFB genes specific to cancer cells compared to their normal counterparts (from the same patients) with more robust over-expression in breast and lung cancer make it a more appropriate target.