Recombinant Rabbit monoclonal primary
Recombinant PDCD4 Monoclonal Antibody (ET1704-70)
A431, PC-3M, Hmuan tonsil tissue, human prostate tissue, human breasr cancer tissue, mouse colon tissue, MCF-7.
Store at +4C after thawing. Aliquot store at -20C or -80C. Avoid repeated freeze / thaw cycles.
1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Protein A purified.
Death up-regulated gene protein antibody; Dug antibody; H731 antibody; Ma3 antibody; MGC33046 antibody; MGC33047 antibody; Neoplastic transformation inhibitor antibody; Neoplastic transformation inhibitor protein antibody; Nuclear antigen H731 antibody; Nuclear antigen H731 like antibody; Nuclear antigen H731 like protein antibody; Nuclear antigen H731-like antibody; PDCD 4 antibody; Pdcd4 antibody; PDCD4_HUMAN antibody; Programmed cell death 4 antibody; programmed cell death 4 (neoplastic transformation inhibitor) antibody; Programmed cell death protein 4 antibody; Protein 197/15a antibody; Protein MA-3 antibody; Tis antibody; Topoisomerase-inhibitor suppressed protein antibody
Belongs to the PDCD4 family.
Up-regulated in proliferative cells. Highly expressed in epithelial cells of the mammary gland. Reduced expression in lung cancer and colon carcinoma.
Polyubiquitinated, leading to its proteasomal degradation. Rapidly degraded in response to mitogens. Phosphorylation of the phosphodegron promotes interaction with BTRC and proteasomal degradation.; Phosphorylated at Ser-67 by RPS6KB1 in response to mitogens; phosphorylation promotes proteasomal degradation of PDCD4.
The transformation suppressor gene Pdcd-4 (programmed cell death gene 4) inhibits the tumor-promoter mediated transformation of mouse keratinocytes and is a potential tumor suppressor gene in the development of human lung cancer. Biochemical analysis suggests that the Pdcd-4 protein is involved in protein translation as well as in nuclear events. Pdcd-4 directly interacts with the RNA helicase eIF4A and inhibits protein synthesis by interfering with the assembly of the cap-dependent translation initiation complex. Pdcd-4 also suppresses the transactivation of AP-1 responsive promoters by c-Jun, suggesting that the transformation-suppressor activity of Pdcd-4 might be due, at least in part, to the inhibition of c-Jun activity. In addition to affecting c-Jun phosphorylation, Pdcd-4 blocks the recruitment of the co-activator p300 by c-Jun.