Lane 1: mouse testis tissue lysate
Lane 2: PC-12 cell lysate
Lane 3: mouse brain tissue lysate
Recombinant Rabbit monoclonal primary
Recombinant OPA1 Monoclonal Antibody (ET1705-9)
Mouse testis tissue lysate, PC-12 cell lysate, mouse brain tissue lysate, Hela, SH-SY5Y, SW480, rat skeletal muscle tissue, human thyroid tissue, human kidney tissue, mouse brain tissue.
Store at +4C after thawing. Aliquot store at -20C. Avoid repeated freeze / thaw cycles.
1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Protein A affinity purified.
Dynamin like 120 kDa protein antibody; Dynamin like 120 kDa protein, mitochondrial antibody; Dynamin-like 120 kDa protein, form S1 antibody; FLJ12460 antibody; Juvenile kjer type optic atrophy antibody; KIAA0567 antibody; KJER type antibody; Large GTP binding protein antibody; largeG antibody; MGM1 antibody; Mitochondrial dynamin like 120 kDa protein antibody; Mitochondrial dynamin like GTPase antibody; NPG antibody; NTG antibody; OAK antibody; OPA 1 antibody; opa1 antibody; OPA1 gene antibody; OPA1_HUMAN antibody; Optic atrophy 1 (autosomal dominant) antibody; OPTIC ATROPHY 1 antibody; Optic atrophy 1 gene protein antibody; Optic atrophy 1 homolog (human) antibody; Optic atrophy protein 1 antibody; Optic atrophy protein 1 homolog antibody
Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family.
Highly expressed in retina. Also expressed in brain, testis, heart and skeletal muscle. Isoform 1 expressed in retina, skeletal muscle, heart, lung, ovary, colon, thyroid gland, leukocytes and fetal brain. Isoform 2 expressed in colon, liver, kidney, thyroid gland and leukocytes. Low levels of all isoforms expressed in a variety of tissues.
PARL-dependent proteolytic processing releases an antiapoptotic soluble form not required for mitochondrial fusion. Cleaved by OMA1 at position S1 following stress conditions.; [Isoform 2]: Cleavage at position S2 is mediated by YME1L. Cleavage may occur in the sequence motif Leu-Gln-Gln-Gln-Ile-Gln (LQQQIQ).; [Isoform 3]: Cleavage at position S2 is mediated by YME1L. Cleavage may occur in the sequence motif Leu-Gln-Gln-Gln-Ile-Gln (LQQQIQ).; [Isoform 4]: Cleavage at position S2 is mediated by YME1L. Cleavage may occur in the sequence motif Leu-Gln-Gln-Gln-Ile-Gln (LQQQIQ).
Mitochondrion inner membrane. Mitochondrion intermembrane space.
OPA1 is a cause of optic atrophy type 1. OPA1 is mostly expressed in the mitochondrial biogenesis. OPA1 is a cause of optic atrophy type 1. OPA1 is mostly expressed In retina but can also be expressed in brain, testis, heart and skeletal muscles.